Seiki Harada

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The aim of this study was to examine if vasodilatory responses to acetylcholine or sodium nitroprusside are altered in subjects with essential hypertension. In patients with essential hypertension (mean BP; 121±4 mmHg,n=14) and age-matched control subjects (mean BP; 88±3 mmHg,n=10), the forearm vasodilatory responses to acetylcholine and sodium(More)
Two-hundred sputum specimens from tuberculosis patients were examined for viable or non-viable mycobacteria by a combination of fluorescein diacetate ethidium bromide (FDA/EB) staining, Ziehl-Neelsen staining, and the use of cultures in 3% Ogawa egg medium. The sputum specimens were treated with 3% NaOH for 10 min and washed in PBS. The bacteria was then(More)
It has been shown that nitric oxide (NO) is synthesized in the central nervous system as well as in vascular endothelial cells. However, the physiological role ofNO in cardiovascular regulation by the central nervous system remains unclear. This objective of this study was to examine the possibility that NO plays a role in neural transmission in the nucleus(More)
The skin test to tuberculin purified protein derivatives (PPD) was examined in 161 cases of newly diagnosed active pulmonary tuberculosis. Tuberculin reaction was reduced in size with aging, and was significantly lower in the age group of 70 years or over than of less than 50. PPD- or PHA-induced proliferation tests of peripheral blood lymphocytes were(More)
An orally effective, nonpeptide vasopressin V, receptor antagonist, OPC-21268 was produced for possible human use. We investigated the effects of OPC-21268 on the vascular effects of intra-arterially infused arginine vasopressin in human forearm vessels. The brachial artery was cannulated for drug infusions and direct measurement of arterial pressure.(More)
Nitric oxide (NO) is shown to be synthesized in the central nervous system as well as in vascular endothelial cells. However, the physiological role of NO in cardiovascular regulation in the central nervous system remains unclear. The present study examines whether NO plays a role in the regulation of neuronal activity in the nucleus tractus solitarius(More)
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