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- John Daniel Nelson, Jun Shimazaki, +4 authors Gary N. Foulks
- Investigative ophthalmology & visual science
- 2011
Recommended definition of MGD: Meibomian gland dysfunction (MGD) is a chronic, diffuse abnormality of the meibomian glands, commonly characterized by terminal duct obstruction and/or… (More)
- Satoru Yoshida, Shigeto Shimmura, +4 authors Kazuo Tsubota
- Investigative ophthalmology & visual science
- 2006
PURPOSE
To elucidate the expression pattern of K15, K19, K14, and K12 in human and mouse ocular surface epithelium as putative markers of epithelial phenotype.
METHODS
Immunohistochemical staining… (More)
PURPOSE
To study changes in the lid margin and meibomian glands and their association with aging, sex, and tear function.
METHODS
We examined 354 eyes in 177 subjects (76 men and 101 women; 21-93… (More)
- Motoko Kawashima, Tetsuya Kawakita, Seika Den, Shigeto Shimmura, Kazuo Tsubota, Jun Shimazaki
- American journal of ophthalmology
- 2006
PURPOSE
To compare the therapeutic outcomes after deep lamellar keratoplasty (DLKP) and penetrating keratoplasty (PKP) in patients with lattice corneal dystrophy (LCD) and macular corneal dystrophy… (More)
- Jun Shimazaki, Seika Den, Masahiro Omoto, Yoshiyuki Satake, Shigeto Shimmura, Kazuo Tsubota
- American journal of ophthalmology
- 2006
PURPOSE
Immunologic rejection remains a major cause of graft failure in high-risk corneal transplantation. This study was conducted to elucidate the efficacy and safety of systemic cyclosporine (CsA)… (More)
Severe donor-related Candida keratitis after Descemet’s stripping automated endothelial keratoplasty
- Katsuya Yamazoe, Seika Den, Takefumi Yamaguchi, Yoichi Tanaka, Jun Shimazaki
- Graefe's Archive for Clinical and Experimental…
- 2011
Fungal keratitis is a rare, but severe, vision-threatening complication following keratoplasty. Fungal infection following penetrating keratoplasty has a reported incidence rate of 0.16% [1, 2]. The… (More)
The concept of transplantation of corneal parts is to replace only diseased tissues, while leaving healthy host tissues intact. Advantages of the new surgical approaches include fast recovery,… (More)
- Seika Den, Chie Sotozono, Shigeru Kinoshita, Tsunehiko Ikeda
- Acta ophthalmologica Scandinavica
- 2004
PURPOSE
To evaluate the effects of early systemic administration of betamethasone or cyclosporin A (CsA) on inflammatory cytokine expression and corneal damage after alkali injury.
METHODS… (More)
- Seika Den, Shigeto Shimmura, Kazuo Tsubota, Jun Shimazaki
- American journal of ophthalmology
- 2007
PURPOSE
To study the influence of the Descemet membrane (DM) perforations after deep lamellar keratoplasty (DLKP) on endothelial decompensation, endothelial density, visual acuity, and postoperative… (More)
AimsTo report five cases of gonococcal keratoconjunctivitis with severe corneal involvement treated with therapeutic keratoplasty.DesignRetrospective case series.MethodsFive consecutive cases of… (More)