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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast
- Seiji Tanaka, Toshiko Umemori, K. Hirai, Sachiko Muramatsu, Y. Kamimura, H. Araki
- 18 January 2007
It is demonstrated that CDKs regulate interactions between BRCT-domain-containing replication proteins and other phosphorylated proteins for the initiation of chromosomal DNA replication; similar regulation may take place in higher eukaryotes.
Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2–7 during G1 phase
It is shown that, like Mcm2–7p, Cdt1p accumulates in the nucleus during G1 phase and is excluded from the nucleus later in the cell cycle by cyclin dependent kinases (cdks).
High-dimensional and large-scale phenotyping of yeast mutants.
- Y. Ohya, J. Sese, S. Morishita
- BiologyProceedings of the National Academy of Sciences…
- 27 December 2005
The high-dimensional phenotypic analysis of defined yeast mutant strains provides another step toward attributing gene function to all of the genes in the yeast genome.
Helicase activation and establishment of replication forks at chromosomal origins of replication.
Functional homologs of these proteins exist in metazoa, although pre-IC formation cannot be separated by requirement of DDK and CDK because of experimental limitations.
Deregulated G1-cyclin expression induces genomic instability by preventing efficient pre-RC formation.
It is shown that overexpression of the G1 cyclin Cln2 inhibits the assembly of prereplicative complexes (pre-RCs) and induces gross chromosome rearrangements (GCR) in budding yeast.
Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control
It is shown here that the mitotic CDK, Clb2/Cdc28, binds tightly to an amino-terminal domain (NTD) of CDC6, and that Cdc6 in this complex is unable to assemble pre-RCs, and it is proposed that direct binding of cyclins to phosphopeptide motifs may be a widespread phenomenon contributing to the targeting of CDKs to substrates.
Corazonin and corazonin-like substances in the central nervous system of the Pterygote and Apterygote insects
Findings support previous findings on the common occurrence of corazonin among insects, except for the albino strain of L. migratoria and the Coleoptera.
Late Quaternary paleoceanographic changes in the Bering Sea and the western subarctic Pacific based on radiolarian assemblages
The role of CDK in the initiation step of DNA replication in eukaryotes
It is proposed that multiple phosphorylation by CDKs controls this process in budding yeast and similar complex formation and, therefore, a similar mechanism of initiation control might be employed in eukaryotes.