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Tetraspanins CD9 and CD81 facilitate the fusion between gametes, myoblasts, or virus-infected cells. Here, we investigated the role of these tetraspanins in the fusion of mononuclear phagocytes. Expression of CD9 and CD81 and their complex formation with integrins were up-regulated when blood monocytes were cultured under normal conditions. Under fusogenic(More)
To examine a possible relation between the swelling-induced ATP release pathway and the volume-sensitive Cl(-) channel, we measured the extracellular concentration of ATP released upon osmotic swelling and whole-cell volume-sensitive Cl(-) currents in a human epithelial cell line, Intestine 407, which lacks expression of cystic fibrosis transmembrane(More)
Cells release adenosine 5'-triphosphate (ATP) into the extracellular space in response to various stimuli. This released ATP plays an important physiological role in cell-to-cell signal transduction. The bulk ATP concentration can be detected using a conventional luciferin-luciferase assay. However, the ATP concentration in the vicinity of the cell surface(More)
Whole-cell clamp experiments revealed the double exponential deactivation of the delayed rectifier K+ current in single guinea pig atrial myocytes. Two types of K(+)-selective channels were identified by applying repolarizing voltage pulses to cell-free patches from atrial cell membrane, where inward-rectifier, ATP-sensitive, and muscarinic K+ channels were(More)
The Wilms' tumor gene WT1 consists of 10 exons and encodes a zinc finger transcription factor. There are four major WT1 isoforms resulting from alternative splicing at two sites, exon 5 (17AA) and exon 9 (KTS). All major WT1 isoforms are overexpressed in leukemia and solid tumors and play oncogenic roles such as inhibition of apoptosis, and promotion of(More)
abstract To examine a possible relation between the swelling-induced ATP release pathway and the volume-sensitive Cl Ϫ channel, we measured the extracellular concentration of ATP released upon osmotic swelling and whole-cell volume-sensitive Cl Ϫ currents in a human epithelial cell line, Intestine 407, which lacks expression of cystic fibrosis transmembrane(More)
Nitric oxide (NO) is known to be a potent messenger in the intracellular signal transduction system in many tissues. In pancreatic beta cells, NO has been reported to be formed from L-arginine through NO synthase. To elucidate the effect of NO on insulin secretion and to investigate the intracellular mechanism of its effect, we have used sodium(More)
In this study, we identify climatic influences on summer monsoon inflow to the Three Gorges Dam (TGD) in the Yangtze River Basin and use indices of these influences to predict streamflow one season ahead. Summer monsoon streamflow at Yichang hydrological station (YHS) was analyzed for the period 1882–2003. Statistical analysis was used to develop a(More)
Complete mitochondrial 16S rRNA gene sequences from 35 caenogastropods were obtained to evaluate the phylogenetic relationship of the family Buccinidae at the intra-supra familial level. With respect to intergeneric relationships within the family, the molecular phylogeny supported three clades with statistical significance: Buccinum + Neptunea, Engina +(More)
We report a preterm infant, who showed abnormal amplitude-integrated electroencephalogram (aEEG) findings 1 h after birth and later developed cystic periventricular leukomalacia (PVL). The patient was a girl with a gestational age of 29 weeks. She was delivered by emergency cesarean section because of placental abruption and intrauterine co-twin demise.(More)