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OBJECTIVES The purpose of this study was to estimate the development of the gyrus and sulcus formation in normal fetuses on the basis of the neuroanatomical findings using MR images in relation to gestational age. METHODS The MR images were obtained from 109 normal fetuses from 18 to 39 weeks of gestation with no neurological problems. The MR images were(More)
Event-related BOLD fMRI data is modeled as a linear time-invariant system. Together with Bayesian inference techniques, a statistical test is developed for rigorously detecting linearity/nonlinearity in the BOLD response system. The test is applied to data collected from eight subjects using an event-related paradigm with a switching checkerboard as the(More)
OBJECTIVES To evaluate the development of myelination in normal fetuses quantitatively using magnetic resonance (MR) imaging in relation to gestational age (GA). METHODS Fetal MR images were obtained from 101 fetuses between 26 and 39 weeks of gestation with no neurological problems. Regions of interest were designated in frontal lobe, corona radiata,(More)
A critical step toward understanding autism spectrum disorder (ASD) is to identify both genetic and environmental risk factors. A number of rare copy number variants (CNVs) have emerged as robust genetic risk factors for ASD, but not all CNV carriers exhibit ASD and the severity of ASD symptoms varies among CNV carriers. Although evidence exists that(More)
OBJECTIVE The purpose of this study was to measure the fetal subarachnoid spaces at different sites of the brain using magnetic resonance (MR) images and analyze them in relation to gestational age. METHODS Fetal MR images were obtained from 158 fetuses between 18 and 39 weeks of gestation who later showed no neurological problems. We bilaterally measured(More)
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