Sei Takahashi

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Aim: LEN is an oral tyrosine kinase inhibitor targeting VEGFR1-3, FGFR1-4, RET, KIT and PDGFRβ, and showed a prominent improvement in progression free survival (PFS) in pts with radioiodine-refractory differentiated thyroid cancer (RR-DTC) in Phase III study. Methods: This is an open-label, multi-center phase II study conducted in Japan in pts with advanced(More)
We examined the genetic transformation of the biotechnologically relevant yeast Rhodotorula gracilis ATCC 26217 by electroporation. To evaluate the yeast transformation, we created a genomic integration cassette that was targeted to the yeast orotidine-5′-phosphate decarboxylase gene (URA3 gene) locus and composed of the zeocin-resistant gene (Sh ble gene)(More)
Radiographically occult bronchogenic squamous cell carcinomas are early lung cancers that localize mainly in the bronchial wall, and are thought to be a good model for investigating genetic alterations through lung cancer progression. In order to elucidate sequential genetic changes in lung cancers, we analysed the incidence of allelic losses on chromosome(More)
  • Sei Takahashi, Yoshihiro Fukuoka, +4 authors Morinobu Takahashi
  • 1984
Complement C2 was isolated from 17 mouse strains by immunoprecipitation and sodium dodecyl sulfate-polyacrylamide gel electrophoresis and examined for structural polymorphism by using micro-peptide mapping. By comparing the peptide maps of tryptic digests of C2 from various strains, two allotypic variations were detected. B 10 and 14 other mouse strains(More)
The Belle detector was designed and constructed to carry out quantitative studies of rare B-meson decay modes with very small branching fractions using an asymmetric e þ e À collider operating at the U(4S) resonance, the KEK-B-factory. Such studies require data samples containing B10 7 B-meson decays. The Belle detector is configured around a 1:5 T(More)
The OPERA neutrino experiment at the underground Gran Sasso Laboratory has measured the velocity of neutrinos from the CERN CNGS beam over a baseline of about 730 km with much higher accuracy than previous studies conducted with accelerator neutrinos. The measurement is based on high-statistics data taken by OPERA in the years 2009, 2010 and 2011. Dedicated(More)
This study revealed the time course of osteoporotic vertebral fracture by magnetic resonance imaging using a simple classification. Signal changes were associated with the compression degree and mobility of the fractured vertebral body. This classification showed sufficient reliability in categorizing magnetic resonance imaging findings of osteoporotic(More)
Computerized interlocking systems have been studied for many years. Available interlocking systems mainly are centralized control systems. The great progress of distributed control technology and intelligent terminals make it possible developing distribute interlocking system. In this research, a distributed interlocking system and its control logic are put(More)