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OBJECTIVE Successful medical management of an ectopic pregnancy is inversely associated with initial hCG level. The purpose of this publication is to assess whether there is a level of hCG above which failure rate substantially increases. DESIGN A systematic review and summary analysis was performed, including studies reporting methotrexate treatment(More)
OBJECTIVE To evaluate the safety and acceptability of a novel dosing regimen of methotrexate to treat ectopic pregnancy. DESIGN Prospective study. SETTING Three academic medical centers. PATIENT(S) One hundred one patients with ectopic pregnancy who elected to have medical therapy. INTERVENTION(S) Intramuscular methotrexate 50 mg/m(2) was(More)
PURPOSE To characterize factors related to the development of hyperprolactinemia and the ensuing reproductive/sexual adverse events in children and adolescents treated with antipsychotic and other psychotropic agents, and the additional risk posed for those with comorbid obesity, metabolic, or endocrine disorders. METHODS A retrospective cohort design(More)
PURPOSE To compare the prevalence of classical risk factors and presenting signs and symptoms between adolescents and adults with ectopic pregnancy (EP). PROCEDURE A database containing information regarding presentation symptoms, past medical history, and ultimate pregnancy outcomes of patients presenting to the Emergency Department during early(More)
STUDY OBJECTIVE Studies have suggested that low vitamin D levels may play a role in the pathogenesis of polycystic ovary syndrome (PCOS). The aim of our study was to compare 25-hydroxyvitamin D [25(OH)D] levels in adolescent females with and without PCOS. DESIGN, SETTING, AND PARTICIPANTS Retrospective chart review at a tertiary care medical center for(More)
OBJECTIVE To evaluate the effect activity has on the vaginal distribution of a 1200 mg miconazole nitrate gelatin encapsulated insert, an antifungal agent commonly used to treat vaginal vulvocandidiasis. METHOD Nine subjects underwent two sessions of serial magnetic resonance imaging after insertion of the insert. One session required that the subjects(More)
BACKGROUND Skene's glands are believed to be homologues of the prostate gland derived from the urogenital sinus.(1) Complications of Skene's glands occur most often in the third and fourth decades and are rarely seen in premenarchal females. CASE A 3-year-old presented to her pediatrician with a 9-day complaint of vulvar pain. Both pediatric and(More)
OBJECTIVE To evaluate the effect of gonorrheal and chlamydial cervicitis (GCC) on the risk of preterm labor (PTL) and preterm premature rupture of membranes (PPROM). STUDY DESIGN A large cross-sectional sample of patients (N = 1,120) was studied. Data on samples for GCC and pregnancy outcome were entered into a database from a retrospective chart review.(More)