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Molecular Pathogenesis, Epidemiology, and Clinical Manifestations of Respiratory Infections Due to Bordetella pertussis and Other Bordetella Subspecies
SUMMARY Bordetella respiratory infections are common in people (B. pertussis) and in animals (B. bronchiseptica). During the last two decades, much has been learned about the virulence determinants,Expand
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Regulation of type III secretion in Bordetella
The BvgAS virulence control system regulates the expression of type III secretion genes in Bordetella subspecies that infect humans and other mammals. We have identified five open reading frames,Expand
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The Bvg virulence control system regulates biofilm formation in Bordetella bronchiseptica.
Bordetella species utilize the BvgAS (Bordetella virulence gene) two-component signal transduction system to sense the environment and regulate gene expression among at least three phases: a virulentExpand
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A genome‐wide screen identifies a Bordetella type III secretion effector and candidate effectors in other species
Bordetella bronchiseptica utilizes a type III secretion system (TTSS) for induction of non‐apoptotic cytotoxicity in host cells and modulation of host immunity. The identity of Bordetella TTSSExpand
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Bordetella Bsp22 forms a filamentous type III secretion system tip complex and is immunoprotective in vitro and in vivo
Type III secretion system (T3SS) tip complexes serve as adaptors that bridge the T3SS needle and the pore‐forming translocation apparatus. In this report we demonstrate that Bsp22, the mostExpand
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Interactions between partner switcher orthologs BtrW and BtrV regulate type III secretion in Bordetella.
We have recently described a multicomponent cascade that regulates type III secretion in Bordetella. This cascade includes a group of proteins, BtrU, BtrW, and BtrV, that contain an array of domainsExpand
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Histophilus somni IbpA DR2/Fic in Virulence and Immunoprotection at the Natural Host Alveolar Epithelial Barrier
ABSTRACT Newly recognized Fic family virulence proteins may be important in many bacterial pathogens. To relate cellular mechanisms to pathogenesis and immune protection, we studied the cytotoxicityExpand
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Cross-Species Protection Mediated by a Bordetella bronchiseptica Strain Lacking Antigenic Homologs Present in Acellular Pertussis Vaccines
ABSTRACT The Bordetella species are Gram-negative bacterial pathogens that are characterized by long-term colonization of the mammalian respiratory tract and are causative agents of respiratoryExpand
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CryoAPEX - an electron tomography tool for subcellular localization of membrane proteins
We describe a method, termed cryoAPEX, that couples chemical fixation and high pressure freezing of cells with peroxidase-tagging (APEX) to allow precise localization of membrane proteins in theExpand
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