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Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

• Carlos A Saura, Se-Young Choi, +9 authors Jie Shen
• Neuron
• 2004

Mutations in presenilins are the major cause of familial Alzheimer's disease, but the pathogenic mechanism by which presenilin mutations cause memory loss and neurodegeneration remains unclear. Here… (More)

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

• Milla Koistinaho, Suizhen Lin, +8 authors Steven M Paul
• Nature Medicine
• 2004

We have previously shown that apolipoprotein E (Apoe) promotes the formation of amyloid in brain and that astrocyte-specific expression of APOE markedly affects the deposition of amyloid-β peptides… (More)

Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice.

• Carlos A Saura, Guiquan Chen, +7 authors Jie Shen
• The Journal of neuroscience : the official…
• 2005

Accumulation of beta-amyloid (Abeta) peptides in the cerebral cortex is considered a key event in the pathogenesis of Alzheimer's disease (AD). Presenilin 1 (PS1) plays an essential role in the… (More)

An egr-1 (zif268) antisense oligodeoxynucleotide infused into the amygdala disrupts fear conditioning.

• Seema Malkani, Karin J. Wallace, Melanie P. Donley, Jeffrey B Rosen
• Learning & memory
• 2004

Studies of gene expression following fear conditioning have demonstrated that the inducible transcription factor, egr-1, is increased in the lateral nucleus of the amygdala shortly following fear… (More)

Specific induction of early growth response gene 1 in the lateral nucleus of the amygdala following contextual fear conditioning in rats

• Seema Malkani, Jeffrey B Rosen
• Neuroscience
• 2000

Although the amygdala is known to be crucial for fear conditioning, little is known about the molecular and cellular mechanisms in the amygdala that are important for fear conditioning. One possible… (More)

Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease.

• Jean-Cosme Dodart, Robert A. Marr, +4 authors Steven M Paul
• Proceedings of the National Academy of Sciences…
• 2005

Apolipoprotein E (apoE) alleles are important genetic risk factors for Alzheimer's disease (AD), with the epsilon4 allele increasing and the epsilon2 allele decreasing risk for developing AD. ApoE… (More)

Differential expression of EGR-1 mRNA in the amygdala following diazepam in contextual fear conditioning.

• Seema Malkani, Jeffrey B Rosen
• Brain research
• 2000

The amygdaloid complex is thought to be a major site of action of anxiolytic benzodiazepine agonists. To investigate whether activity in the amygdaloid complex is altered with anxiolytic effects of… (More)

Induction of NGFI-B mRNA following contextual fear conditioning and its blockade by diazepam.

• Seema Malkani, Jeffrey B Rosen
• Brain research. Molecular brain research
• 2000

Expression of the immediate-early gene, NGFI-B (nerve growth factor inducible gene B), was examined in the amygdala, hippocampus, and neocortex following contextual fear conditioning. Rats were… (More)

N-Methyl-D-aspartate receptor antagonism blocks contextual fear conditioning and differentially regulates early growth response-1 messenger RNA expression in the amygdala: implications for a…

• Seema Malkani, Jeffrey B Rosen
• Neuroscience
• 2001

N-Methyl-D-aspartate receptors in the amygdala are known to be crucial for the learning of conditioned fear, although the molecular cascades that N-methyl-D-aspartate receptors regulate are not well… (More)

Differential expression of <ce:italic>EGR-1</ce:italic> mRNA in the amygdala following diazepam in contextual fear conditioning

• Seema Malkani, Jeffrey B Rosen
• Brain Research
• 2000

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