Seema Kulkarni

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The Janus-associated kinase 2 (JAK2) V617F mutation is believed to play a critical role in the pathogenesis of polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis. The discovery of activating mutations associated with inhibition of cascade of events mediated by JAK2 target became an attractive approach for the treatment of(More)
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