Seema Chakravarti

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Plasma cell myeloma (PCM) is an essentially incurable neoplastic disorder of terminally differentiated B cells. The neoplastic clone usually secretes a monoclonal protein in the serum or urine (the 'M band'). About 20% of PCM secrete light chains only, which are detectable in the urine as Bence Jones protein. The clinical picture is one of bone marrow(More)
A 34-year-old multiparous woman presented at 22(+6) weeks' gestation with severe abdominal pain which preceded a mechanical fall down the stairs. On admission, fetal movements were felt and fetal heart rate was detected by Doppler ultrasound. Over the course of 12 h, although she maintained her vital signs, repeat laboratory and radiological investigations(More)
Pyruvate kinase deficiency (PKD) is a rare non-spherocytic type of haemolytic anaemia. During pregnancy, women with severe PKD are at increased risk of infection, thrombosis, hypertension, fetal growth restriction and anaemia. Management of such cases requires close collaboration between a haematologist and an obstetrician. We report a case of severe PKD in(More)
BACKGROUND Secretory immunity is a major defence mechanism against infections at mucosal surfaces which are common in HIV infected patients. AIMS To analyse intestinal immunoglobulin production in HIV infection in comparison with that in saliva and serum. PATIENTS AND METHODS Immunoglobulin G (IgG), A (IgA), and M (IgM) concentrations were determined in(More)
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