Sebastian Wutzler

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BACKGROUND The role of acute coagulopathy after traumatic brain injury (TBI) on outcome has gained increasing appreciation over the recent years. This study was conducted to assess the frequency, outcome, and risk factors associated with this complication. PATIENTS AND METHODS Using the large, multi-center population-based Trauma Registry of the German(More)
BACKGROUND The incidence of pulmonary failure in trauma patients is considered to be influenced by several factors such as liver injury. We intended to assess the association of various potential predictors of pulmonary failure following thoracic trauma and liver injury. METHODS Records of 12,585 trauma patients documented in the TraumaRegister DGU® of(More)
INTRODUCTION Retrospective studies have demonstrated a potential survival benefit from transfusion strategies using an early and more balanced ratio between fresh frozen plasma (FFP) concentration and packed red blood cell (pRBC) transfusions in patients with acute traumatic coagulopathy requiring massive transfusions. These results have mostly been derived(More)
Dendritic cells (DCs) represent an important linkage between the innate and adaptive immune system and express proinflammatory transcriptomic products early after trauma. The use of a genomic approach recently revealed that platelet factor 4 (PF4) is significantly upregulated in DCs in patients after multiple trauma. However, knowledge about subsequent PF4(More)
BACKGROUND Major trauma patients (TP) developing imbalanced immune response are at high risk for infectious post-injury complications including pneumonia. Neutrophils play a central role in the host defense against bacteria and thereby pathogenesis of infections. While there are numerous studies about neutrophil function after trauma, data about their(More)
Dendritic cells (DC) represent an important linkage between the innate and adoptive immune system and express pro-inflammatory transcriptomic products early after trauma. Using a genomic approach, platelet factor 4 (PF4) was recently found significantly up-regulated in DCs following multiple trauma. However, knowledge about subsequent PF4 alteration and its(More)
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