Sebastian Seiler

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Heart failure with preserved ejection fraction (HFPEF) evolves with the accumulation of risk factors. Relevant animal models to identify potential therapeutic targets and to test novel therapies for HFPEF are missing. We induced hypertension and hyperlipidemia in landrace pigs (n = 8) by deoxycorticosteroneacetate (DOCA, 100 mg/kg, 90-day-release(More)
OBJECTIVE We tested whether mild hypothermia impacts on circulatory and respiratory dysfunction during experimental endotoxemia. DESIGN Randomized controlled prospective experimental study. SETTING Large animal facility, Medical University of Graz, Austria. SUBJECTS Thirteen anesthetized and mechanically ventilated pigs. INTERVENTIONS(More)
BACKGROUND Mild hypothermia (MH) decreases infarct size and mortality in experimental reperfused myocardial infarction, but may potentiate ischaemia-induced left ventricular (LV) diastolic dysfunction. METHODS In anaesthetized pigs (70 ± 2 kg), polystyrol microspheres (45 μm) were infused repeatedly into the left circumflex artery until cardiac power(More)
Michael Schwarzl, Nazha Hamdani, Sebastian Seiler, Alessio Alogna, Martin Manninger, Svetlana Reilly, Birgit Zirngast, Alexander Kirsch, Paul Steendijk, Jochen Verderber, David Zweiker, Philipp Eller, Gerald Höfler, Silvia Schauer, Kathrin Eller, Heinrich Maechler, Burkert M. Pieske, Wolfgang A. Linke, Barbara Casadei, and Heiner Post Department of General(More)
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