Sebastian Schneider

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The idea of sodium ions altering G-protein-coupled receptor (GPCR) ligand binding and signaling was first suggested for opioid receptors (ORs) in the 1970s and subsequently extended to other GPCRs. Recently published ultra-high-resolution crystal structures of GPCRs, including that of the δ-OR subtype, have started to shed light on the mechanism underlying(More)
The topic of motivation is a crucial issue for various human-robot interaction (HRI) scenarios. Interactional aspects of motivation can be studied in human-human interaction (HHI) and build the basis for modeling a robot’s interactional conduct. Using an ethnographic approach we explored the factors relevant in the formation of motivationrelevant processes(More)
New perspectives have been developed to understand the processes of modeling heterogeneous membranes. These are crucial steps prior to applying advanced techniques like molecular dynamic simulations of whole membrane systems. Lipid, protein, and membrane packing problems are addressed based on biochemical properties in combination with computational(More)
In recent years vehicles have been equipped with more and more sensors for environment perception. Among these sensors are cameras, RADAR, single-layer and multi-layer LiDAR. One key challenge for the fusion of these sensors is sensor calibration. In this paper we present a novel extrinsic calibration algorithm based on sensor odometry. Given the(More)
Targeted migration of muscle precursor cells to the anlagen of limb muscles is a complex process, which is only partially understood. We have used Lbx1 mutant mice, which are unable to establish correct migration paths of muscle precursor cells into the limbs to identify new genes involved in the accurate placement of myogenic cells in developing muscles.(More)
We present a concept for long-term feedback during robot assisted indoor cycling training. Our feedback model captures different aspects from sport motivation theory. Furthermore, we present our designed measurements to evaluate the robot's persuasiveness and user's compliance. We conducted an intensive 18-day isolation study in two campaigns (e.g. socially(More)
Substantial attention has recently been devoted to G protein-biased agonism of the μ-opioid receptor (MOR) as an ideal new mechanism for the design of analgesics devoid of serious side effects. However, designing opioids with appropriate efficacy and bias is challenging because it requires an understanding of the ligand binding process and of the allosteric(More)
Engineers developing socially assistive robots for promoting a healthy and active lifestyle are facing several mechanical and interactive design challenges. In this paper we are answering the question whether a humanoid robot exercising partner capable of working out together with its user makes significant improvement in the user’s engagement. We conducted(More)