Sebastian Schürmann

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Progressive force loss in Duchenne muscular dystrophy is characterized by degeneration/regeneration cycles and fibrosis. Disease progression may involve structural remodeling of muscle tissue. An effect on molecular motorprotein function may also be possible. We used second harmonic generation imaging to reveal vastly altered subcellular sarcomere(More)
We present an approach for the computation of single-object velocity statistics in a noisy fluorescence image series. The algorithm is applied to molecular imaging data from an in vitro actin-myosin motility assay. We compare the relative efficiency of wavelet and curvelet transform denoising in terms of noise reduction and object restoration. It is shown(More)
The pore size of biopolymer networks governs their mechanical properties and strongly impacts the behavior of embedded cells. Confocal reflection microscopy and second harmonic generation microscopy are widely used to image biopolymer networks; however, both techniques fail to resolve vertically oriented fibers. Here, we describe how such directionally(More)
Decision making in cellular ensembles requires the dynamic release of signaling molecules from the producing cells into the extracellular compartment. One important example of molecules that require regulated release in order to signal over several cell diameters is the Hedgehog (Hh) family, because all Hhs are synthesized as dual-lipidated proteins that(More)
Practically, all chronic diseases are characterized by tissue remodeling that alters organ and cellular function through changes to normal organ architecture. Some morphometric alterations become irreversible and account for disease progression even on cellular levels. Early diagnostics to categorize tissue alterations, as well as monitoring progression or(More)
Assessing disease activity is a prerequisite for an adequate treatment of inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. In addition to endoscopic mucosal healing, histologic remission poses a promising end-point of IBD therapy. However, evaluating histological remission harbors the risk for complications due to the(More)
  • Sebastian Schürmann, Dieter Spath, Andreas Rößler, Hannes Rose, Florian Rothfuss, Dionysios Satikidis +3 others
  • 2015
— Durch die Verbreitung der Elektromobilität werden Ladestationen immer wichtiger. Sie erhalten ei-nen kleinen Einblick im Bereich der Schnellladeverfahren. Dabei im Vordergrund steht besonders die DC-Schnellladestation. Zusammenfassung—Diese Veröffentlichung setzt sich mit den Problemen und Ansätzen der Parameteridentifikation bei perma-nentmagneterregten(More)
We present an approach to skeletal muscle contractility and its regulation over different scales ranging from biomechanical studies in intact muscle fibers down to the motility and interaction of single motor protein molecules. At each scale, shortening velocities as a measure for weak cross-bridge cycling rates are extracted and compared. Experimental(More)
Manifest disease associated with decreased motor-cortex reactivity in twins discordant for schizophrenia. Improved differentiation of tactile activations in human secondary somatosensory cortex and thalamus using cardiac-triggered fMRI. Activation of the human primary motor cortex during observation of tool use. Activation of the human posterior parietal(More)
After a review of the research on the effectiveness of the different treatment modalities used in multimodal treatment of children with hyperkinetic disorders, a decision tree is described for planning multimodal treatment for school-aged children. Differences in treating preschool children are discussed. A mulitmodal treatment program for children with(More)
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