Sebastian Oliver Decker

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Oxygen affects the activity of multiple skeletogenic cells and is involved in many processes that are important for fracture healing. However, the role of oxygen in fracture healing has not been fully studied. Here we systematically examine the effects of oxygen tension on fracture healing and test the ability of hyperoxia to rescue healing defects in a(More)
Bloodstream infections remain one of the major challenges in intensive care units, leading to sepsis or even septic shock in many cases. Due to the lack of timely diagnostic approaches with sufficient sensitivity, mortality rates of sepsis are still unacceptably high. However a prompt diagnosis of the causative microorganism is critical to significantly(More)
BACKGROUND The origin of osteoblasts is still controversial. Whereas several authors consider the stromal fibroblast of the bone marrow as the osteoprogenitor cell, others propose that the osteoblasts can be derived from the "capillary system." The present study examines the replacement of tricalciumphosphate (TCP)-ceramic implanted into an artificial bone(More)
Intramedullary nailing is a common method for fixation of femoral diaphyseal shaft fractures. However, postoperative malrotation does occur in 20–30 % of patients, as intraoperative assessment of antetorsion remains difficult. The estimated average antetorsion angle is 15°. However, it is not clear whether antetorsion correlates with individual(More)
Pharmacokinetic half-life of prednisolone is 2–3 h, indicating short pharmacodynamic effect duration. Therefore, the fractionated twice daily administration of prednisolone might be favorable. A 6-month observational study was conducted in a total of 51 patients, 35 with glomerulonephritis and 16 with kidney transplants. Low-dose and long-term prednisolone(More)
AIM The aim of this study was to check the feasibility and accuracy of measuring antetorsion during surgery using a mobile image intensifier (IF) with computed tomography (CT) function (ISO-C 3D; Siemens, Erlangen, Germany) in comparison to a conventional multi-slice CT scanner (LightSpeed QX/I CT; GE Healthcare, VA, USA). MATERIALS AND METHODS A total of(More)
Neoangiogenesis plays an important role in tumor growth and metastasis. Evaluation of new anti-angiogenic targets may broaden the armament for future therapeutic concepts. Focal adhesion kinase (FAK), expressed in endothelial and tumor cells, is essential for adhesion and mobility of adherent cells. In the current study we analyzed the anti-angiogenic(More)
Systemic inflammation is an immune response to a nonspecific insult of either infectious or noninfectious origin and remains a challenge in the intensive care units with high mortality rate. Cholinergic neurotransmission plays an important role in the regulation of the immune response during inflammation. We hypothesized that the activity of(More)
BACKGROUND Optimal therapy for anterior cruciate ligament (ACL) rupture in the paediatric population still provokes controversy. Although conservative and operative treatments are both applied, operative therapy is slightly favored. Among available surgical techniques are physeal-sparing reconstruction and transphyseal graft fixation. The aim of this study(More)
The anterolateral ligament (ALL) has been proposed as a possible extra-articular stabiliser of the knee. Injury to the ALL may result in residual instability following surgical reconstruction of a ruptured anterior cruciate ligament (ACL). Few studies have evaluated the biomechanical role of the ALL. The purpose of this study was to investigate whether(More)