Sebastian Mohr

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Spleen tyrosine kinase (Syk) induces cell survival and proliferation in a high proportion of acute myeloid leukemia (AML) blasts, but the underlying molecular events of Syk signaling have not been investigated. Proteomic techniques have allowed us to identify the multiprotein complex that is nucleated by constitutively active Syk in AML cells. This complex(More)
In-depth analyses of cancer cell proteomes are needed to elucidate oncogenic pathomechanisms, as well as to identify potential drug targets and diagnostic biomarkers. However, methods for quantitative proteomic characterization of patient-derived tumors and in particular their cellular subpopulations are largely lacking. Here we describe an experimental(More)
To enable extensive experimentation with peer-to-peer (P2P) systems in a controlled environment, we have implemented a P2P system in a network simulation framework. In this paper, we explain the implementation process and the design issues we faced. 1 Motivation In the recent past, peer-to-peer (P2P) systems have generated a lot of interest in the research(More)
The transcription factor Meis1 drives myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undruggable. We therefore investigated whether myeloid progenitor cells transformed by Hoxa9 and Meis1 become addicted to targetable signaling pathways. A comprehensive (phospho)proteomic analysis revealed that Meis1 increased(More)
This paper, analyzing interviews with men that donate their semen in Denmark, explores what it means to be a sperm donor. Breaking with the assumption that men have a specific and clearly identifiable motivation to become sperm donors, this paper leaves the confinement of such an accountable actor model implied in asking for men's motivations to donate(More)
The flux-energy distribution functions of H + 3 ions at the electrodes of capacitively coupled parallel plate discharges operated in a regime of relatively high gas pressures (200–650 Pa) are investigated experimentally using (differentially pumped) energy-resolved mass spectrometry under various conditions and compared with the results of a numeric(More)
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