Sebastian Kuhn

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BACKGROUND Previous studies of both clinically-derived and in vitro passage-derived daptomycin-resistant (DAP-R) Staphylococcus aureus strains demonstrated the coincident emergence of increased DAP MICs and resistance to host defense cationic peptides (HDP-R). METHODS In the present investigation, we studied a parental DAP-susceptible (DAP-S)(More)
INTRODUCTION When decompression of the lumbar spinal canal is performed, segmental stability might be affected. Exactly which anatomical structures can thereby be resected without interfering with stability, and when, respectively how, additional stabilization is essential, has not been adequately investigated so far. The present investigation describes(More)
INTRODUCTION Previous studies have shown that the number of myoblastically differentiated fibroblasts known as myofibroblasts (MFs) is significantly increased in stiff joint capsules, indicating their crucial role in the pathogenesis of post-traumatic joint stiffness. Although the mode of MFs' function has been well defined for different diseases associated(More)
Soft tissue complications are clinically relevant problems after osteosynthesis of fractures. The goal is to develop a method for reduction of fibroblast adhesion and proliferation on titanium implant surfaces by plasma polymerisation of the organo-silicon monomer hexamethyldisiloxane (HMDSO). HMDSO was deposited under continuous wave conditions in excess(More)
BACKGROUND Currently, antegrade intramedullary nailing and minimally invasive plate osteosynthesis (MIPO) represent the main surgical alternatives in distal tibial fractures. However, neither choice is optimal for all bony and soft tissue injuries. The Retrograde Tibial Nail (RTN) is a small-caliber prototype implant, which is introduced through a 2-cm-long(More)
UNLABELLED Phospholipids are synthesized at the inner leaflet of the bacterial cytoplasmic membrane but have to be translocated to the outer leaflet to maintain membrane lipid bilayer composition and structure. Even though phospholipid flippases have been proposed to exist in bacteria, only one such protein, MprF, has been described. MprF is a large(More)
Using the CLAS detector at Jefferson Lab, double spin asymmetries (A ||) for quasi-elastic electron scattering off the deuteron have been measured at several beam energies. The data were collected during the EG1 experiment, which scattered longitudinally polarized electrons with energies from 1.6 to 5.8 GeV off a longitudinally polarized cryogenic ND 3(More)
Introduction Successful regeneration of intra-oral osseous and periodontal defects requires adequate host tissue reactions with recruitment and subsequent activation (and protection) of relevant adjacent cell populations. Indispensable for the formation of new mineralised bony tissue and re-organisation of tooth supporting structures are osteogenic cells(More)
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