Sebastian Koball

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BACKGROUND Whether antibiotic treatment in patients with enterohemorrhagic Escherichia coli (EHEC)-associated diarrhea influences the risk of hemolytic uremic syndrome (HUS) has still to be elucidated. PATIENTS AND METHODS During the EHEC epidemic which occurred in northern Germany in spring 2011, 24 patients with E. coli O104:H4 infection were treated at(More)
the ICU stay the patient was in clinical need for renal replacement therapy and therefore started on citrate anticoagulated continuous venovenous hemodiafiltration (CVVHD, Multifiltrate, FMC, Bad Homburg, Germany). As the interleukin-6 (IL6) level was elevated to 665 pg/ml (normal range <5.4 pg/ml), a hemoadsorption column (Cytosorb; Cytosorbents GmbH,(More)
Clinically Isolated Syndromes (CIS) summarize clinical features of possible multiple sclerosis (MS) as a first clinical event of the disease. Escalation therapy in CIS episodes comprises high dose glucocorticosteroid (GCS) treatment followed by therapeutic plasma exchange (TPE) in patients unresponsive to GCS. The aim of our study was to analyze TPE effects(More)
OBJECTIVES Experience with therapeutic plasma exchange (TPE) for acute relapses in clinically isolated syndrome (CIS) or multiple sclerosis (MS) patients has been derived from small and inhomogeneous patient populations so far. In the present study, we retrospectively evaluated features associated with TPE response in a larger cohort of CIS and MS patients(More)
The left-ventricular stroke volume is an important direct indicator of the heart efficiency and perfusion of the vessels. Currently a valid measurement of the beat volume can only be implemented by invasive measurements procedures at the hospitals worldwide. Arterial catheterization is limited to intensive care unit (ICU) usage, costly and potential risky.(More)
INTRODUCTION Neutrophil granulocytes are the first defense line in bacterial infections. However, granulocytes are also responsible for severe local tissue impairment. In order to use donor granulocytes, but at the same time to avoid local side effects, we developed an extracorporeal immune support system. This first-in-man study investigated whether an(More)
Neutrophils are critical effector cells in humoral and innate immunity and play a vital role in phagocytosis and bacterial killing. If they and/or their specific functions are lacking, then immunoparalysis may occur, and severe diseases like systemic inflammatory response syndrome (SIRS) or sepsis can take a fatal course. In this paper, we discuss the(More)
Non-invasive continuous real-time assessment of patient conditions for the diagnostic purposes is a target of the state-of-the-art clinical monitoring technology. Such a surveillance system for the peripheral vascular diagnostics was designed during current research by combining the pulse spectroscopy and advanced signal processing. Analysis of the rhythmic(More)
BACKGROUND Albumin is an important transport protein for non-water-soluble protein-bound drugs and uraemic toxins. Its transport capacity is reduced in patients with advanced chronic kidney disease (CKD) and unbound fractions of uraemic toxins are related to complications of CKD. We investigated whether this reduction could be quantified and how it(More)