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Immuno-enzymosomes have been proposed for the targeting of enzymes to cancer cells to achieve site specific activation of anticancer prodrugs. Previously, we reported that the enzyme beta-glucuronidase (GUS), capable of activating anthracycline-glucuronide prodrugs, can be coupled to the surface of inmunoliposomes directed against human ovarian cancer cells… (More)
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Ocean salinity is a critical component to understanding climate change. Salinity concentrations and temperature drive large ocean currents which in turn drive global weather patterns. Melting ice caps lower salinity at the poles while river deltas bring fresh water into the ocean worldwide. These processes slow ocean currents, changing weather patterns and… (More)