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Subspace clustering has been investigated extensively since traditional clustering algorithms often fail to detect meaningful clusters in high-dimensional data spaces. Many recently proposed subspace clustering methods suffer from two severe problems: First, the algorithms typically scale exponentially with the data dimensionality and/or the subspace(More)
With the advent of technologies that allow simultaneous genotyping of thousands of single-nucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach to Alzheimer disease (AD). We present(More)
OBJECTIVES To identify current developments, obstacles, and opportunities for health information systems. METHODS International reports were discussed during an IMIA HIS Working Conference with a focus on architectural design, project goals and drivers, obstacles, and opportunities. RESULTS Technology and standards are available to build regional and(More)
OBJECTIVES To identify current challenges and developments in health information systems. METHODS Reports on HIS, eHealth and process support were analyzed, core problems and challenges were identified. RESULTS AND CONCLUSION Health information systems are extending their scope towards regional networks and health IT infrastructures. Integration,(More)
Diese Arbeit beschreibt die Architektur eines IT-Systems zur Erfassung und Verwaltung vonP atientendaten undB ioproben in einemd eutschlandweiten Netzwerk,d as im Rahmen des Verbundprojektes mitoNET vomB MBFg efördert wird.A ufgrund der sensiblen Daten liegt einb esonderer Schwerpunkt aufD aten-schutz undI T-Sicherheitsaspekten; u.a. werden kryptographische(More)
Nach der Entschlüsselung des menschlichen Genoms ergeben sich für die medizinische Forschung weitreichende Möglichkeiten, die auf Informations-integration und der Zusammenführung phänotypischer und genotypischer Daten beruhen. Um die komplexen Integrationsanforderungen der medizinischen Domäne handhaben zu können, wird ein inkrementeller Ansatz(More)