Sebastian Fleischhauer

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The nitroreductase/5-(azaridin-1-yl)-2,4-dinitrobenzamide (NTR/CB1954) enzyme/prodrug system is considered as a promising candidate for anti-cancer strategies by gene-directed enzyme prodrug therapy (GDEPT) and has recently entered clinical trials. It requires the genetic modification of tumor cells to express the E. coli enzyme nitroreductase that(More)
The oxidation of closo-heteroborates [GeB11H11](2-) and [SnB11H11](2-) is presented. Upon oxidation germa-closo-dodecaborate yields a symmetrical dimer exhibiting a Ge-Ge bond between two clusters. This dimer shows sulphur insertion into the Ge-Ge bond at room temperature. In contrast, oxidation of the homologous tin cluster results in an unsymmetrical(More)
The heteroborate stanna-closo-dodecaborate shows double substitution in the reaction with alkylated acetonitrile. The reaction product, the charge compensated E,E-isomer, was isomerized into the Z,Z-isomer and hydrogenated at the double bonds. Furthermore the methylated cluster shows less reactivity and the monosubstituted cluster was isolated. The reaction(More)
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