Sebastian Aspinall

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BACKGROUND Human rotavirus vaccine (HRV; i.e., Rotarix) reduced the incidence of severe rotavirus gastroenteritis (RVGE) by 77% (95% Confidence interval: 56-88%) during the first year of life in South Africa. Persistence of HRV-derived protection against RVGE during subsequent rotavirus seasons, although evident in industrialized settings, remains to be(More)
During 1989 stool specimens from hospitalised children with gastroenteritis at Ga-Rankuwa Hospital in South Africa were examined for the presence of rotaviruses. Overall 16% of the children were positive for rotavirus. However, 43% of the rotavirus positive patients were infected in the hospital. Further characterisation of the rotavirus strains was(More)
Different hepatitis C virus (HCV) genotypes may be associated with viral load, severity of liver disease, hepatocellular carcinoma, geographical location and sensitivity to interferon. In this study the prevalence of HCV-RNA and distribution of HCV genotypes was investigated in anti-HCV-positive patients admitted to Ga-Rankuwa Hospital during 1994 and 1995.(More)
Serological markers for evidence of past exposure to hepatitis B virus (HBV) and hepatitis C virus (HCV) were investigated in a cohort of refugees from Mozambique. Serological markers for past exposure to HBV were detected in 56% of the population and, in addition, 13.2% carried the HBV surface antigen. Anti-HCV antibodies could be confirmed in 3.2% of the(More)
A community based sero-epidemiological study was undertaken to determine the age specific prevalence rates of hepatitis A virus (HAV) and hepatitis B virus (HBV) infection in a band of Bushmen in the West Caprivi, Namibia. All children tested and all but two of the adults tested showed the presence of anti-HAV antibodies. Nineteen individuals (18%) were(More)
Objective and Design: To determine the effects of anti-inflammatory and anti-rheumatic drugs on paw swelling and changes in plasma levels of acute phase proteins (APPs) during acute inflammation in the rat.¶Materials and Methods: Inflammation was induced in rats by the injection of adjuvant and the animals were bled five days later and plasma levels of(More)
Women with mammary hypertrophy undergoing mastectomy for breast cancer suffer disability because of disproportionate asymmetry. The case notes of all women with mammary hypertrophy undergoing mastectomy and immediate contra-lateral reduction mammaplasty for primary breast cancer from February 2001 to December 2008 were reviewed. Thirty-three women were(More)
A novel beta-lactamase enzyme produced by a strain of Pseudomonas paucimobilis is described. The enzyme differs from other recorded beta-lactamases from Gram-negative aerobic bacteria. It was constitutive, and had the characteristics of a penicillinase. One single band of beta-lactamase activity at pI 4.6 was seen on iso-electric focusing. The enzyme had a(More)
BACKGROUND A low-cost, 'flash' heat-inactivated hepatitis B vaccine with enhanced immunogenicity allowing for a relatively low dose (Hepaccine B; Cheil Foods and Chemicals, Korea) was introduced into the South African Expanded Programme on Immunisation during 1995 to immunise infants against hepatitis B. To determine the seroresponse of this vaccine in(More)