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Journals and Conferences
The tight regulation of synchronous Ca-dependent vesicle release is well captured by the allosteric model developed by Lou et al. . We previously proposed the Arrhenius equation to be the… (More)
Short-term synaptic plasticity (STP) is essential for information processing and working memory. Post-tetanic potentiation (PTP) induced by high-frequency stimulation (HFS) is thought to depend on… (More)
Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate Sebastiaan Schotten, et al.
The energy required to fuse synaptic vesicles with the plasma membrane ('activation energy') is considered a major determinant in synaptic efficacy. From reaction rate theory, we predict that a class… (More)
Fast release of neurotransmitters from the presynapse is known to depend on the coupling between synaptic vesicles and presynaptic Ca channels. While the average coupling distance has been estimated… (More)
Synaptotagmin-1 (Syt-1) has been found to play both a stimulating and inhibitory role during synaptic vesicle fusion. Removal of Syt-1 abolishes the fast phase of action potential-induced release,… (More)