Sebastián Martínez-Castillo

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Ocular inflammatory disorders constitute a sight-threatening group of diseases that might be managed according to their severity. Their treatment guidelines experience constant changes with new agents that improve the results obtained with former drugs. Nowadays we can make use of a five step protocol in which topical, periocular and systemic(More)
We used (1)H NMR spectroscopy to analyze the metabolomic profile of reflex tears from patients with dry eye disorders (DEDs). 90 subjects were divided into 2 groups: (1) patients with DEDs (DEDG; n = 55) and (2) healthy subjects (CG; n = 35). Additionally, the DEDG was subdivided into 2 subgroups based on DED severity: mild-to-moderate and moderate (n = 22(More)
PURPOSE We used nuclear magnetic resonance spectroscopy of hydrogen-1 nuclei ((1)H NMR S) to analyze the metabolic profile of reflex tears from patients with dry eye disorders. METHODS We performed a prospective case-control study involving 90 participants: 55 patients diagnosed with dry eye syndrome (DESG) and 35 healthy subjects (control group, CG).(More)
BACKGROUND Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury. OBJECTIVE We reviewed the role of OS and its downstream signaling in aging eyes. METHODS A search of the(More)
Dear Editor, We read with great interest the case report entitled “Intravitreal ranibizumab in retinal macroaneurysm” by Wenkstern et al. [1] regarding the effects of intravitreal ranibizumab (Lucentis®; Genentech, Inc, South San Francisco, CA, USA) as monotherapy for retinal arterial macroaneurysms (RAM). RAM are acquired retinal vascular abnormalities,(More)
The purpose of this study was to compare the efficacy of intravitreal ranibizumab in the treatment of macular edema due to branch retinal vein occlusions (BRVO) with and without serous macular neuroretinal detachment (SMD). Forty-nine eyes of 49 patients with macular edema due to branch retinal vein occlusion (22 with SMD and 27 without SMD) were included(More)
PURPOSE To report a case of Coats' disease managed with the dexamethasone intravitreal implant Ozurdex(®) (Allergan, Inc., Irvine, Calif., USA) combined with retinal photocoagulation. METHODS A 46-year-old female with 20/200 visual acuity was diagnosed with Coats' disease with secondary retinal vasoproliferative tumor. An initial approach was performed(More)
Dear Editor, Macular laser photocoagulation (focal or modified grid) is still the gold standard therapy for macular edema due to retinal vascular pathologies [1, 2]. Its main goal is to solve the leakage arising from macular vessels by photocoagulating photoreceptors [3]. This reduces the oxygen consumption of the outer retina, and allows the oxygen to(More)
Dear Editor, Dr Gupta confirms that we are living actually in the era of optical coherence tomoghraphy (OCT). We do agree with the point that the OCT reveals static information only, whereas fluorescein angiography (FA) is a dynamic investigation. However, the static information is very considerably more precise with OCT than any clue given by the FA with(More)