Sebastián Lipina

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At variance with current descriptions stressing the stellate geometry of cortical astrocytes in the brain of adult mammals, GFAP-immunoreactive astrocytes from prefrontal and rostral cingulate cortices in two adult New World monkey species, Cebus apella and Saimiri sciureus, were found to have long cellular processes traversing several cortical lamina.(More)
 Previous observations have shown that astrocytes with interlaminar processes are present in the cerebral cortex of humans and New and Old World monkeys, but not in the rodent. The present report furthers the analysis of possible evolutionary aspects regarding the expression of such astroglial features. A comparison between young and adult Microcebus(More)
UNLABELLED Long astroglial processes traversing several cortical laminae appear to be characteristic of primate brains. Whether interlaminar processes develop as a modification of radial glia or are truly postnatal elements stemming from stellate astroglia, could be assessed by analyzing their early developmental stages. A survey of glial fibrillar acidic(More)
Bilateral astroglial transplantation into the neostriatum of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys resulted in significant performance improvement in a spatial delayed response task, but failed to modify perseveration in an object retrieval detour task, or to improve motor clinical rating. Results suggest that brain circuits(More)
Long, interlaminar, astroglial processes and its patterned organization in the striate cortex of adult primates was previously described. Loss of visual input following bilateral retinal detachment and degeneration in an adult Cebus apella monkey resulted three months later in reduction of interlaminar processes immunoreactive to Glial Fibrillary Acid(More)
Executive functions (EF) in children can be trained, but it remains unknown whether training-related benefits elicit far transfer to real-life situations. Here, we investigate whether a set of computerized games might yield near and far transfer on an experimental and an active control group of low-SES otherwise typically developing 6-y-olds in a 3-mo(More)
At variance with the rodent, presence of long glial fibrillary acid protein-immunoreactive (GFAP-IR) astroglial processes traversing several cortical laminae (interlaminar processes) appears to be characteristic of the primate cerebral cortex. Their permanence or changes may constitute a significant factor in the functional alterations that develop after(More)
Although the study of brain development in non-human animals is an old one, recent imaging methods have allowed non-invasive studies of the gray and white matter of the human brain over the lifespan. Classic animal studies show clearly that impoverished environments reduce cortical gray matter in relation to complex environments and cognitive and imaging(More)
The appearance of developmental cognitive neuroscience (DCN) in the socioeconomic status (SES) research arena is hugely transformative, but challenging. We review challenges rooted in the implicit and explicit assumptions informing this newborn field. We provide balanced theoretical alternatives on how hypothesized psychological processes map onto the brain(More)
Studies based on animal and human models have shown structural and functional alterations in the Central Nervous System after exposure to early enriched, or deprived, environments. Poverty, as a complex phenomenon of environmental deprivation, was repeatedly associated with deleterious consequences for early cognitive functioning. This study compares the(More)