Sean Z. Goodin

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BACKGROUND The surgical treatment for obesity promotes massive weight loss and early improvement in co-morbid conditions such as type-2 diabetes. Because surgically mediated glycemic improvements are immediate, the mechanisms involved appear to be weight loss independent. Ileal interposition has been used to gain understanding of the relative role that the(More)
Agouti-related peptide (AgRP), the endogenous antagonist to the melanocortin 3 and 4 receptors, elicits robust hyperphagia and weight gain in rodents when administered directly into the central nervous system. The relative influence of AgRP to cause weight gain in rodents partially depends on the activity level of the melanocortin agonist-producing(More)
1 Agouti-related peptide (AgRP), the endogenous antagonist to the melanocortin 3 2 and 4 receptors, elicits robust hyperphagia and weight gain in rodents when 3 administered directly into the central nervous system. The relative influence of AgRP to 4 cause weight gain in rodents partially depends on the activity level of the melanocortin 5(More)
PURPOSE Ileal interposition recapitulates many of the metabolic improvements similar to Roux-en-Y gastric bypass. We aimed to determine whether the metabolic improvements seen following ileal interposition were conferred solely by the interposed segment by examining changes in neighboring intestinal segments as well as the composition of the bile acid pool.(More)
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