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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants.
TLDR
It is found that truncation fusions of yeast FIP1 analogous to those in cancer cause loss of function and that siRNA knockdown of FIP 1L1 in human cells increases DNA damage and chromosome breakage.
An E4 Ligase Facilitates Polyubiquitination of Plant Immune Receptor Resistance Proteins in Arabidopsis[W]
TLDR
The Arabidopsis thaliana E4 ligase MUSE3 facilitates the polyubiquitination of immune receptor resistance proteins, including SNC1 and RPS2, leading to more efficient degradation of the target substrates, and provides insight into the scarcely understood NLR degradation pathway.
Biogenesis of RNA Polymerases II and III Requires the Conserved GPN Small GTPases in Saccharomyces cerevisiae
TLDR
This study shows that the nuclear import defect of iwr1Δ, but not the GPN2 or GPN3 mutant defects, is partially suppressed by fusion of a nuclear localization signal to the RNA polymerase II subunit Rpb3, and suggests that theGPN proteins function upstream of Iwr1 in RNA polymerases II and III biogenesis.
Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance
TLDR
A mechanism by which oncogenic RAS preserves intracellular redox balance is uncovers and an unexpected role for xCT is identified in supporting RAS-induced transformation and tumorigenicity is identified.
Saccharomyces cerevisiae Genetics Predicts Candidate Therapeutic Genetic Interactions at the Mammalian Replication Fork
TLDR
This work identifies hub genes and processes that are candidate targets for synthetic lethal killing of cancer cells with defined somatic mutations, and affirm not only replication stress but also the targeting of DNA replication fork proteins themselves as potential targets for anticancer therapeutic development.
ARID1A regulates R-loop associated DNA replication stress
TLDR
It is shown that ARID1A loss leads to DNA replication stress associated with R-loops and transcription-replication conflicts in human cells, which correlates with altered transcription and replication dynamics in ARIDs1A knockout cells and to reduced TOP2A binding at R-loop sites.
ARID1A regulates R-loop associated DNA replication stress
TLDR
It is shown that ARID1A loss leads to DNA replication stress associated with R-loops and transcription-replication conflicts in human cells, and this effects correlate with altered transcription and replication dynamics in ARIDs1A knockout cells and to reduced TOP2A binding at R-loop sites.
A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis
TLDR
Overall, this screen shows the exquisite specificity of GPN2 for RNA polymerase transport, and reveals a previously unappreciated role for CTD modification in RNAPII nuclear localization.
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