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Vegas is a new implementation of TCP that achieves between 40 and 70% better throughput, with one-fifth to one-half the losses, as compared to the implementation of TCP in the Reno distribution of BSD Unix. This paper motivates and describes the three key techniques employed by Vegas, and presents the results of a comprehensive experimental performance(More)
As le systems grow i n size, ensuring that data is safely stored becomes more and more diicult. Historically , le system backup strategies have focused on logical backup where les are written in their entirety to the backup media. An alternative i s p h ys-ical backup where the disk blocks that make up the le system are written to the backup media. This(More)
Network software is a critical component of any distributed system. Because of its complexity, network software is commonly layered into a hierarchy of protocols, or more generally, into a <italic>protocol graph</italic>. Typical protocol graphs&#8212;including those standardized in the ISO and TCP/IP network architectures&#8212;share three important(More)
This white paper describes Scout, a new operating system being designed for systems connected to the National Information Infrastructure (NII). Scout provides a communication-oriented software architecture for building operating system code that is specialized for the different systems that we expect to be available on the NII. It includes an explicit path(More)
x-kernel is an experimental operating system for personal workstations that allows uniform access to resources throughout a nationwide internet: an interconnection of networks similar to the TCP/IP internet. This network is also called the National Research and Education Network (NREN). The x-kernel supports a library of protocols, and it accesses different(More)
The m-Bop protein encoded by the mouse Bop gene is strongly expressed in heart and skeletal muscle, and recent studies with Bop knockout mice have demonstrated that m-Bop is essential for cardiogenesis in vivo and can act as a HDAC-dependent repressor in vitro. In the present studies, m-Bop was observed to interact with skNAC, a reported transcriptional(More)
Furin plays a crucial role in embryogenesis and homeostasis and in diseases such as Alzheimer's disease, cancer, and viral and bacterial infections. Thus, inhibition of furin may provide a feasible and promising approach for therapeutic intervention of furin-mediated disease mechanisms. Here, we report on a class of small molecule furin inhibitors based on(More)
We describe an adaptation of the rolling circle amplification (RCA) reporter system for the detection of protein Ags, termed "immunoRCA. " In immunoRCA, an oligonucleotide primer is covalently attached to an Ab; thus, in the presence of circular DNA, DNA polymerase, and nucleotides, amplification results in a long DNA molecule containing hundreds of copies(More)
The Diie-Hellman key exchange algorithm can be implemented using the group of points on an elliptic curve over the eld F 2 n. A software version of this using n = 155 can be optimized to achieve computation rates that are signiicantly faster than non-elliptic curve versions with a similar level of security. The fast computation of reciprocals in F 2 n is(More)
Male Sprague-Dawley rats, trained to consume their daily energy needs in a single 3-h meal (0900-1200 h), were used to examine the hypothesis that polyunsaturated fatty acids (PUFA) lowered the nuclear content of sterol regulatory element binding protein (SREBP)-1 and/or -2 by suppressing the proteolytic release of mature SREBP from the membrane-anchored(More)