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- Yoshio Miki, Jeff Swensen, +7 authors W. Ding
- Science
- 1994
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have… (More)
- Audrey Petitjean, Ewy Mathe, +4 authors Magali Olivier
- Human mutation
- 2007
The tumor suppressor gene TP53 is frequently mutated in human cancers. More than 75% of all mutations are missense substitutions that have been extensively analyzed in various yeast and human cell… (More)
- Alexander Kamb, Nelleke A. Gruis, +7 authors Mark H. Skolnick
- Science
- 1994
A putative tumor suppressor locus on the short arm of human chromosome 9 has been localized to a region of less than 40 kilobases by means of homozygous deletions in melanoma cell lines. This region… (More)
- Sam Aparicio, Jarrod Chapman, +37 authors S. Brenner
- Science
- 2002
The compact genome of Fugu rubripes has been sequenced to over 95% coverage, and more than 80% of the assembly is in multigene-sized scaffolds. In this 365-megabase vertebrate genome, repetitive DNA… (More)
- Stephen A. Goff, Darrell O Ricke, +52 authors Steven Briggs
- Science
- 2002
The genome of the japonica subspecies of rice, an important cereal and model monocot, was sequenced and assembled by whole-genome shotgun sequencing. The assembled sequence covers 93% of the… (More)
- Peter A. Steck, Mark A. Pershouse, +12 authors Sean V. Tavtigian
- Nature Genetics
- 1997
Deletions involving regions of chromosome 10 occur in the vast majority (>90%) of human glioblastoma multiformes. A region at chromosome 10q23–24 was implicated to contain a tumour suppressor gene… (More)
- Sean V. Tavtigian, Amie M. Deffenbaugh, +6 authors Aurélie Thomas
- Journal of medical genetics
- 2006
BACKGROUND
Genetic testing for hereditary cancer syndromes contributes to the medical management of patients who may be at increased risk of one or more cancers. BRCA1 and BRCA2 testing for… (More)
- David E. Goldgar, Douglas F. Easton, Amie M. Deffenbaugh, Alvaro N. A. Monteiro, Sean V. Tavtigian, Fergus J. Couch
- American journal of human genetics
- 2004
Many sequence variants in predisposition genes are of uncertain clinical significance, and classification of these variants into high- or low-risk categories is an important problem in clinical… (More)
- Thomas S. Frank, Amie M. Deffenbaugh, +8 authors Gregory C. Critchfield
- Journal of clinical oncology : official journal…
- 2002
PURPOSE
To assess the characteristics that correlate best with the presence of mutations in BRCA1 and BRCA2 in individuals tested in a clinical setting.
PATIENTS AND METHODS
The results of 10,000… (More)
- Alexander K.C. Wong, Ralph S. Pero, Patricia A. Ormonde, Sean V. Tavtigian, Paul L. Bartel
- The Journal of biological chemistry
- 1997
Recent work has shown that the murine BRCA2 tumor suppressor protein interacts with the murine RAD51 protein. This interaction suggests that BRCA2 participates in DNA repair. Residues 3196-3232 of… (More)