Sean R McGee

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As a first step toward understanding how rare variants contribute to risk for complex diseases, we sequenced 15,585 human protein-coding genes to an average median depth of 111× in 2440 individuals of European (n = 1351) and African (n = 1088) ancestry. We identified over 500,000 single-nucleotide variants (SNVs), the majority of which were rare (86% with a(More)
Dilated cardiomyopathy commonly causes heart failure and is the most frequent precipitating cause of heart transplantation. Familial dilated cardiomyopathy has been shown to be caused by rare variant mutations in more than 30 genes but only ~35% of its genetic cause has been identified, principally by using linkage-based or candidate gene discovery(More)
We have measured the branching fraction and photon energy spectrum for the radiative penguin process b → sγ. We find B(b → sγ) = (3.21 ± 0.43 ± 0.27 −0.10) × 10 , where the errors are statistical, systematic, and from theory corrections. We obtain first and second moments of the photon energy spectrum above 2.0 GeV, 〈Eγ〉 = 2.346± 0.032± 0.011 GeV, and 〈E(More)
B. Aharmim,6 S. N. Ahmed,14 A. E. Anthony,17,* N. Barros,8 E. W. Beier,13 A. Bellerive,4 B. Beltran,1 M. Bergevin,5,7 S. D. Biller,12 K. Boudjemline,4 M. G. Boulay,14 T. H. Burritt,19 B. Cai,14 Y. D. Chan,7 D. Chauhan,6 M. Chen,14 B. T. Cleveland,12 G. A. Cox,19 X. Dai,4,12,14 H. Deng,13 J. Detwiler,7 M. DiMarco,14 P. J. Doe,19 G. Doucas,12 P.-L. Drouin,4(More)
B. Aharmim, S. N. Ahmed, E.W. Beier, A. Bellerive, S. D. Biller, J. Boger, M. G. Boulay, T. J. Bowles, S. J. Brice, T.V. Bullard, Y. D. Chan, M. Chen, X. Chen, B.T. Cleveland, G. A. Cox, X. Dai, F. Dalnoki-Veress, P. J. Doe, R. S. Dosanjh, G. Doucas, M. R. Dragowsky, C. A. Duba, F. A. Duncan, M. Dunford, J. A. Dunmore, E. D. Earle, S. R. Elliott, H. C.(More)
G. Brandenburg, A. Ershov, D.Y.-J. Kim, R. Wilson, K. Benslama, B. I. Eisenstein, J. Ernst, G. D. Gollin, R. M. Hans, I. Karliner, N. Lowrey, M. A. Marsh, C. Plager, C. Sedlack, M. Selen, J. J. Thaler, J. Williams, K.W. Edwards, R. Ammar, D. Besson, X. Zhao, S. Anderson, V.V. Frolov, Y. Kubota, S. J. Lee, S. Z. Li, R. Poling, A. Smith, C. J. Stepaniak, J.(More)
We present preliminary results of several analyses searching for the effects of CP violation and mixing in the decay ofD0 mesons. We find no evidence of CP asymmetry in five different two-body decay modes of the D0 to pairs of light pseudo-scalar mesons: ACP (K +K−) = (+0.05±2.18±0.84)%, ACP (π+π−) = (+2.0±3.2±0.8)%, ACP (K0 Sπ) = (+0.1±1.3)%, ACP (π0π0) =(More)
B. Aharmim, S. N. Ahmed, J. F. Amsbaugh, A. E. Anthony, J. Banar, N. Barros, E.W. Beier, A. Bellerive, B. Beltran, M. Bergevin, S. D. Biller, K. Boudjemline, M.G. Boulay, T. J. Bowles, M. C. Browne, T. V. Bullard, T. H. Burritt, B. Cai, Y.D. Chan, D. Chauhan, M. Chen, B. T. Cleveland, G.A. Cox-Mobrand, C. A. Currat, X. Dai, H. Deng, J. Detwiler, M. DiMarco,(More)
Several rare European von Willebrand disease missense variants of VWF (including p.Arg2185Gln and p.His817Gln) were recently reported to be common in apparently healthy African Americans (AAs). Using data from the NHLBI Exome Sequencing Project, we assessed the association of these and other VWF coding variants with von Willebrand factor (VWF) and factor(More)