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Borrelia burgdorferi EbfC, a Novel, Chromosomally Encoded Protein, Binds Specific DNA Sequences Adjacent to erp Loci on the Spirochete's Resident cp32 Prophages
- K. Babb, T. Bykowski, Sean P. Riley, M. C. Miller, E. Demoll, B. Stevenson
- Biology, MedicineJournal of bacteriology
- 15 June 2006
The isolation and characterization of a novel, chromosomally encoded protein, EbfC, that binds specific DNA sequences located immediately 5' of all erp loci is described, one of the first site-specific DNA-binding proteins to be identified in any spirochete.
Adherence to and Invasion of Host Cells by Spotted Fever Group Rickettsia Species
Current knowledge of the essential pathogenic processes of adherence to and invasion of host cells, efforts to disrupt these processes, and potential for disease prevention through vaccination with recently identified bacterial adherence and invasion proteins are described.
Host-Directed Antimicrobial Drugs with Broad-Spectrum Efficacy against Intracellular Bacterial Pathogens
A library of 640 Food and Drug Administration-approved compounds for agents that render THP-1 cells resistant to infection by four intracellular pathogens was screened, identifying several FDA-approved drugs that inhibit the growth of intrACEllular bacteria, thereby implicating host intrace cellular pathways presumably utilized by bacteria during infection.
Lyme borreliosis spirochete Erp proteins, their known host ligands, and potential roles in mammalian infection.
- C. Brissette, Anne E. Cooley, +5 authors B. Stevenson
- Biology, MedicineInternational journal of medical microbiology…
- 1 September 2008
Results suggest that Erp proteins play roles in multiple aspects of mammalian infection, including binding host proteins such as the complement regulator factor H and the extracellular matrix component laminin.
Genetic and physiological characterization of the Borrelia burgdorferi ORF BB0374-pfs-metK-luxS operon.
- Sean P. Riley, T. Bykowski, K. Babb, Kate von Lackum, B. Stevenson
- Biology, MedicineMicrobiology
- 1 July 2007
The present studies demonstrate that a single B. burgdorferi operon encodes both of the enzymes responsible for synthesis of DPD, as well as the enzyme for production of the Lyme spirochaete's only activated-methyl donor and a probable phosphohydrolase.
Borrelia burgdorferi Regulates Expression of Complement Regulator-Acquiring Surface Protein 1 during the Mammal-Tick Infection Cycle
- Kate von Lackum, Jennifer C. Miller, +6 authors R. Wallich
- Biology, MedicineInfection and Immunity
- 1 November 2005
Comparisons of CRASP-1 expression patterns with those of other infection-associated B. burgdorferi proteins, including the OspC, OspA, and Erp proteins, indicated that each protein is regulated through a unique mechanism.
Synthesis of Autoinducer 2 by the Lyme Disease Spirochete, Borrelia burgdorferi
- K. Babb, Kate von Lackum, R. Wattier, Sean P. Riley, B. Stevenson
- Medicine, BiologyJournal of bacteriology
- 1 May 2005
The present studies demonstrated that B. burgdorferi encodes functional Pfs and LuxS enzymes for the breakdown of toxic products of methylation reactions and was shown to synthesize the end product 4,5-dihydroxy-2,3-pentanedione (DPD) during laboratory cultivation.
Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins
- Sean P. Riley, T. Bykowski, +10 authors B. Stevenson
- Biology, MedicineNucleic acids research
- 10 February 2009
The present work defines the DNA sequence required for high-affinity binding by EbfC to be the 4 bp broken palindrome GTnAC, where ‘n’ can be any nucleotide.
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells
- Pedro Curto, I. Simões, Sean P. Riley, J. Martínez
- Biology, MedicineFront. Cell. Infect. Microbiol.
- 29 July 2016
A phenotypic difference between a non-pathogenic and a pathogenic SFG member lies in their respective ability to proliferate in macrophage-like cells, and may provide an explanation as to why certain SFG rickettsial species are not associated with disease in mammals.
The Rickettsia conorii Autotransporter Protein Sca1 Promotes Adherence to Nonphagocytic Mammalian Cells
- Sean P. Riley, K. Goh, Timothy M. Hermanas, Marissa M. Cardwell, Y. Y. Chan, J. Martínez
- Medicine, BiologyInfection and Immunity
- 22 February 2010
It is demonstrated that attachment to mammalian cells can be uncoupled from the entry process and that Sca1 is involved in the adherence of R. conorii to host cells.