Sean P. Sheehy

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Stem cell-derived cardiomyocytes represent unique tools for cell- and tissue-based regenerative therapies, drug discovery and safety, and studies of fundamental heart-failure mechanisms. However, the degree to which stem cell-derived cardiomyocytes compare to mature cardiomyocytes is often debated. We reasoned that physiological metrics of engineered(More)
Advances in stem cell manufacturing methods have made it possible to produce stem cell-derived cardiac myocytes at industrial scales for in vitro muscle physiology research purposes. Although FDA-mandated quality assurance metrics address safety issues in the manufacture of stem cell-based products, no standardized guidelines currently exist for the(More)
Peach, K.J., Aslaninejad, M., Barlow, R.J., Beard, C.D., Bliss, N., Cobb, J.H., Easton, M.J., Edgecock, R., Fenning, R., Gardner, I.S.K., Hill, M.A., Owen, H.L., Johnstone, C.J., Jones, B., Jones, T., Kelliher, D.J., Khan, A., Machida, S., McIntosh, P.A., Pattalwar, S., Pasternak, J., Pozimski, J., Prior, C.R., Rochford, J., Rogers, C.T., Seviour, Rebecca,(More)
The PAMELA project(Particle Accelerator For MEdical Applications) currently consists of the design of a particle therapy facility. The project, which is in the design phase, contains Non-Scaling FFAG, particle accelerator capable of rapid beam acceleration, giving a pulse repetition rate of 1kHz, far beyond that of a conventional synchrotron. To realise the(More)
Peach, K.J., Aslaninejad, M., Barlow, R.J., Beard, C.D., Bliss, N., Cobb, J.H., Easton, M.J., Edgecock, R., Fenning, R., Gardner, I.S.K., Hill, M.A., Owen, H.L., Johnstone, C.J., Jones, B., Jones, T., Kelliher, D.J., Khan, A., Machida, S., McIntosh, P.A., Pattalwar, S., Pasternak, J., Pozimski, J., Prior, C.R., Rochford, J., Rogers, C.T., Seviour, Rebecca,(More)
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