Sean P. McGlynn

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Cell fate specification in the CNS is controlled by the secreted morphogen sonic hedgehog (Shh). At spinal cord levels, Shh produced by both the notochord and floor plate (FP) diffuses dorsally to organize patterned gene expression in dividing neural and glial progenitors. Despite the fact that two discrete sources of Shh are involved in this process, the(More)
The symmetric pattern of codon degeneracies is discussed by using empirical arguments processed within a group-theoretic framework. It is reasoned that the genetic code is a relation rather than a mapping, and the symmetry of a relation defined on the codons is investigated. The principal results are (i) a new extraction of the basic symmetry inherent in(More)
We describe an integrative approach to the modeling of biophysical radiation effects. The model takes aim at practical applications of the knowledge provided by molecular studies of radiation-matter interactions in DNA. The central proposition is the idea that the distribution of molecular lesions (i.e., a molecular lesion spectrum, MLS) generated in DNA by(More)
The electronic structures of several derivatives of cinnamic acid have been studied by UV photoelectron spectroscopy (UPS) and Green's function quantum chemical calculations. The spectra reveal the presence of dimers in the gas phase for p-coumaric and ferulic acids. The electronic structure analysis has been related to the biological properties of these(More)