Sean O'Leary

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This research employed a descriptive case study design to compare subjects' performance using three computer input devices: the Tongue Touch Keypad, the HeadMaster, and the mouthstick. The sample consisted of four students with severe physical disabilities enrolled in an adaptive computer class at a community college. Components of performance examined were(More)
Vesicle trafficking in eukaryotic cells is facilitated by SNARE-mediated membrane fusion. The ATPase NSF (N-ethylmaleimide-sensitive factor) and the adaptor protein α-SNAP (soluble NSF attachment protein) disassemble all SNARE complexes formed throughout different pathways, but the effect of SNARE sequence and domain variation on the poorly understood(More)
N(6)-methylation of adenosine (forming m(6)A) is the most abundant post-transcriptional modification within the coding region of mRNA, but its role during translation remains unknown. Here, we used bulk kinetic and single-molecule methods to probe the effect of m(6)A in mRNA decoding. Although m(6)A base-pairs with uridine during decoding, as shown by X-ray(More)
Rett Syndrome (RTT) is a severe neurodevelopmental disorder characterized by an apparently normal development followed by an arrest and subsequent regression of cognitive and psychomotor abilities. At present, RTT has no definitive cure and the treatment of RTT represents a largely unmet clinical need. Following partial elucidation of the underlying(More)
The effects of vitamin D are mediated through the vitamin D receptor (VDR), a predominantly nuclear receptor, expressed in numerous tissues including the placenta. VDR and the retinoid X receptor (RXR) form a dimer complex which binds to genomic vitamin D responsive elements located primarily in promoter regions and recruit cell-specific transcription(More)
Sound texture synthesis has applications in creating audio scenes for film and video games. In this paper, a novel algorithm for sound texture synthesis is presented. The goal of this algorithm is to produce new examples of a given sampled texture, the synthesized textures being of any desired duration. The algorithm is based on a montage approach to(More)
In this paper a novel algorithm for sound texture synthesis is presented. The goal of this algorithm is to produce new examples of a given sampled texture, the synthesized textures being of any desired duration. The algorithm is based on a montage approach to synthesis in that the synthesized texture is made up of pieces of the original sample concatenated(More)
A displaced Long Head of Biceps (LHB) tendon is commonly encountered in association with subscapularis rotator cuff tears. Management options for the displaced tendon consist of tenotomy, tenodesis or relocation with reconstruction of the biceps pulley. We present 16 patients in whom LHB relocation and reconstruction of the biceps pulley, was performed in(More)
The use of free gesture in making music has usually been confined to instruments that use direct mappings between movement and sound space. Here we demonstrate the use of categories of gesture as the basis of musical learning and performance collaboration. These are used in a system that reinterprets the approach to learning through performance that is(More)
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