Sean Maxwell

Learn More
The precise molecular etiology of obstructive sleep apnea (OSA) is unknown; however recent research indicates that several interconnected aberrant pathways and molecular abnormalities are contributors to OSA. Identifying the genes and pathways associated with OSA can help to expand our understanding of the risk factors for the disease as well as provide new(More)
Sequences up to several megabases in length have been found to be present in individual genomes but absent in the human reference genome. These sequences may be common in populations, and their absence in the reference genome may indicate rare variants in the genomes of individuals who served as donors for the human genome project. As the reference genome(More)
Interactions among genomic loci (also known as epistasis) have been suggested as one of the potential sources of missing heritability in single locus analysis of genome-wide association studies (GWAS). The computational burden of searching for interactions is compounded by the extremely low threshold for identifying significant p-values due to multiple(More)
Alzheimer's and Parkinson's diseases (AD and PD) are two common neurodegenerative diseases primarily affecting memory and motor functions, respectively. In this study, we integrated data from various sources, and took a systems-biology approach to compare and contrast the molecular and network based dysregulation associated with AD and PD and we integrated(More)
In systems biology, the solution space for a broad range of problems is composed of sets of functionally associated biomolecules. Since connectivity in molecular interaction networks is an indicator of functional association, such sets can be identified from connected induced subgraphs of molecular interaction networks. Applications typically quantify the(More)
Background.  Human immunodeficiency virus (HIV) patients who experience poor CD4 T-cell recovery despite viral suppression during antiretroviral therapy (ART) are known as immunological nonresponders. The molecular mechanism(s) underlying incomplete immune restoration during ART is not fully understood. Methods.  Label-free quantitative proteomics on(More)
Mycobacterium tuberculosis (Mtb) cell wall glycolipid Mannose-capped Lipoarabinomannan (ManLAM) inhibits CD4+ T cell activation by inhibiting proximal T cell receptor (TCR) signaling when activated by anti-CD3. To understand the impact of ManLAM on CD4+ T cell function when both the TCR-CD3 complex and major co-stimulator CD28 are engaged, we performed(More)
Activation of protein phosphatase 2A (PP2A) is a promising anticancer therapeutic strategy, as this tumor suppressor has the ability to coordinately downregulate multiple pathways involved in the regulation of cellular growth and proliferation. In order to understand the systems-level perturbations mediated by PP2A activation, we carried out mass(More)
Motivation In recent years, various network proximity measures have been proposed to facilitate the use of biomolecular interaction data in a broad range of applications. These applications include functional annotation, disease gene prioritization, comparative analysis of biological systems and prediction of new interactions. In such applications, a major(More)
  • 1