Sean M. Wasserman

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Contents Why do we need this guide? 5 Principles for rational antibiotic prescribing 6 Interpreting test results 11 Correct techniques of microbiological sampling 13 Changing antibiotics 15 Infection prevention 16 Acute upper respiratory tract infection 20 Lower respiratory tract infection 24 Intra-­‐abdominal infection 29 Acute diarrhoea 31 Urinary tract(More)
BACKGROUND To develop a community-based model of stroke care, we assessed discharge planning of stroke patients, available resources and continuity of care between hospital and community in a remote rural setting in South Africa. We sought to determine outcomes, family participation and support needs, and implementation of secondary prevention strategies.(More)
A 25-year-old man received methadone hydrochloride maintenance therapy for heroin addiction. Choreic movements involving the upper limbs, torso, and speech mechanisms developed. Discontinuation of methadone resulted in complete alleviation of the abnormal movements with no recurrence during the subsequent eight months. To our knowledge, this is the first(More)
BACKGROUND Stroke is an important cause of death and disability in sub-Saharan Africa. Recombinant tissue plasminogen activator (tPA) thrombolysis is effective in treating acute ischaemic stroke, but may not be a viable option in developing countries. METHODS We assessed the short-term outcomes and safety of tPA for the treatment of stroke at Groote(More)
To the Editor: My 85-year-old father has been a lifelong smoker, he remains fit and well and writes a blog about the pleasure he gets from smoking and the benefits in terms of weight loss. Another 127 85-year-old lifelong smokers have written to him saying they have also maintained a normal weight throughout their lives; they feel
BACKGROUND Reports from Africa have suggested that pneumocystis pneumonia (PCP) is a less important cause of morbidity than in the developed world. However, more recent studies have shown high seroprevalence rates of P. jirovecii in healthy individuals with HIV as well as high rates of clinical disease in African children. This suggests that PCP may be more(More)
AIM To conduct a prospective assessment of anti-hepatitis E virus (HEV) IgG seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for exposure. METHODS Consenting participants attending clinics and wards of Groote Schuur, Red Cross Children's Hospital and their affiliated teaching hospitals in Cape Town,(More)
BACKGROUND Seroprevalence data and clinical studies in children suggest that the burden of pneumocystis pneumonia (PCP) in Africa may be underestimated. We performed a systematic review to determine the prevalence and attributable mortality of PCP amongst HIV-infected adults in sub-Saharan Africa. METHODS We searched Pubmed, Web of Science, Africa-Wide:(More)
This paper utilizes a sample of firms over the years 2000–2009 to test the effects of credit rating changes, the financial crisis, interest rates, and other variables on short-term, long-term, and total debt levels on the balance sheet. Each independent variable was created using a one year lag in order to run the regressions. The values of these variables(More)
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