Sean L. Hill

Krembil Centre for Neuroinformatics, CAMH, University of Toronto, EPFL
0000-0001-8055-860X
https://krembilneuroinformatics.ca
Publications81
h-index28
Citations5,668
Highly Influential Citations388
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  • Publications
  • Influence
The Sleep Slow Oscillation as a Traveling Wave
TLDR
It is shown here that each cycle of the slow oscillation is a traveling wave, which provides a blueprint of cortical excitability and connectivity and may play a role in spike timing-dependent synaptic plasticity during sleep. Expand
Reconstruction and Simulation of Neocortical Microcircuitry
TLDR
A first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat is presented, finding a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. Expand
Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties
TLDR
Key features of the somatic and dendritic firing of L5b pyramidal cells in adult rats are characterized and a useful way to analyze model parameters with their sets of models is shown, which enabled them to identify some of the mechanisms responsible for the dynamic properties of L 5b pyramsidal cells as well as mechanisms that are sensitive to morphological changes. Expand
Modeling sleep and wakefulness in the thalamocortical system.
TLDR
The model is the first to integrate intrinsic neuronal properties with detailed thalamocortical anatomy and reproduce neural activity patterns in both wakefulness and sleep, thereby providing a powerful tool to investigate the role of sleep in information transmission and plasticity. Expand
New insights into the classification and nomenclature of cortical GABAergic interneurons
TLDR
A possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria is described. Expand
Reduced sleep in Drosophila Shaker mutants
TLDR
It is shown that short-sleeping Shaker flies have a reduced lifespan, and that mns flies carry a point mutation in a conserved domain of the Shaker gene, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release and may regulate sleep need or efficiency. Expand
A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
TLDR
It is found that, depending on a number of factors, the LFP reflects local and cross-layer processing, and active currents dominate the generation of LFPs, not synaptic ones. Expand
Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves.
TLDR
Experimental results from rat cortical depth recordings and human high-density EEG show similar changes in slow-wave parameters with decreasing SWA, suggesting that the underlying mechanism may indeed be a net decrease in synaptic strength. Expand
Sleep homeostasis in Drosophila melanogaster.
TLDR
TheSleep homeostatic response in fruit flies is a stable phenotype and shares most of, if not all, the major features of mammalian sleep homeostasis, thus supporting the use of Drosophila as a model system for the genetic dissection of sleep mechanisms and functions. Expand
BigNeuron: Large-Scale 3D Neuron Reconstruction from Optical Microscopy Images
TLDR
BigNeuron is a new community effort that combines modern bioimaging informatics, recent leaps in labeling and microscopy, and the widely recognized need for openness and standardization to provide a community resource for automated reconstruction of dendritic and axonal morphology of single neurons. Expand
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