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The Sleep Slow Oscillation as a Traveling Wave
- M. Massimini, R. Huber, F. Ferrarelli, Sean L. Hill, G. Tononi
- BiologyThe Journal of Neuroscience
- 4 August 2004
It is shown here that each cycle of the slow oscillation is a traveling wave, which provides a blueprint of cortical excitability and connectivity and may play a role in spike timing-dependent synaptic plasticity during sleep.
Reconstruction and Simulation of Neocortical Microcircuitry
Models of Neocortical Layer 5b Pyramidal Cells Capturing a Wide Range of Dendritic and Perisomatic Active Properties
Key features of the somatic and dendritic firing of L5b pyramidal cells in adult rats are characterized and a useful way to analyze model parameters with their sets of models is shown, which enabled them to identify some of the mechanisms responsible for the dynamic properties of L 5b pyramsidal cells as well as mechanisms that are sensitive to morphological changes.
Modeling sleep and wakefulness in the thalamocortical system.
The model is the first to integrate intrinsic neuronal properties with detailed thalamocortical anatomy and reproduce neural activity patterns in both wakefulness and sleep, thereby providing a powerful tool to investigate the role of sleep in information transmission and plasticity.
New insights into the classification and nomenclature of cortical GABAergic interneurons
- J. DeFelipe, Pedro L. López-Cruz, G. Ascoli
- Computer Science, BiologyNature Reviews Neuroscience
- 1 March 2013
A possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria is described.
Reduced sleep in Drosophila Shaker mutants
It is shown that short-sleeping Shaker flies have a reduced lifespan, and that mns flies carry a point mutation in a conserved domain of the Shaker gene, which encodes a voltage-dependent potassium channel controlling membrane repolarization and transmitter release and may regulate sleep need or efficiency.
A Biophysically Detailed Model of Neocortical Local Field Potentials Predicts the Critical Role of Active Membrane Currents
Sleep homeostasis and cortical synchronization: I. Modeling the effects of synaptic strength on sleep slow waves.
Experimental results from rat cortical depth recordings and human high-density EEG show similar changes in slow-wave parameters with decreasing SWA, suggesting that the underlying mechanism may indeed be a net decrease in synaptic strength.
Sleep homeostasis in Drosophila melanogaster.
- R. Huber, Sean L. Hill, Carie E. Holladay, Melissa Biesiadecki, G. Tononi, C. Cirelli
- Biology, PsychologySleep
- 15 June 2004
TheSleep homeostatic response in fruit flies is a stable phenotype and shares most of, if not all, the major features of mammalian sleep homeostasis, thus supporting the use of Drosophila as a model system for the genetic dissection of sleep mechanisms and functions.
Statistical connectivity provides a sufficient foundation for specific functional connectivity in neocortical neural microcircuits
- Sean L. Hill, Yun Wang, Imad Riachi, F. Schürmann, H. Markram
- BiologyProceedings of the National Academy of Sciences
- 18 September 2012
It is found that random alignment of axonal and dendritic arbors provides a sufficient foundation for specific functional connectivity to emerge in local neural microcircuits, suggesting that chemospecific steering and aligning of the arbors may occur for some types of connections.