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Medical message boards are online resources where users with a particular condition exchange information, some of which they might not otherwise share with medical providers. Many of these boards contain a large number of posts and contain patient opinions and experiences that would be potentially useful to clinicians and researchers. We present an approach(More)
PURPOSE While patients often use the internet as a medium to search for and exchange health-related information, little is known about the extent to which patients use social media to discuss side effects related to medications. We aim to understand the frequency and content of side effects and associated adherence behaviors discussed by breast cancer(More)
PURPOSE Sudden cardiac death (SD) and ventricular arrhythmias (VAs) caused by medications have arisen as an important public health concern in recent years. The validity of diagnostic codes in identifying SD/VA events originating in the ambulatory setting is not well known. This study examined the positive predictive value (PPV) of hospitalization and(More)
OBJECTIVE The authors sought to determine whether use of methylphenidate in adults is associated with elevated rates of serious cardiovascular events compared with rates in nonusers. METHOD This was a cohort study of new users of methylphenidate based on administrative data from a five-state Medicaid database and a 14-state commercial insurance database.(More)
The use of propensity scores to adjust for measured confounding factors has become increasingly popular in cohort studies. However, their use in case-control and case-cohort studies has received little attention. The authors present some theory on the estimation and use of propensity scores in case-control and case-cohort studies and present the results of(More)
OBJECTIVE To measure the incidence of cancer in patients with psoriasis, stratified by the severity of their disease. DESIGN A cohort study. SETTING Administrative claims records obtained from Medicaid programs in 3 US states. PARTICIPANTS All individuals in the claims database who qualified for 1 of the 5 following groups: severe psoriasis as defined(More)
BACKGROUND Acute renal failure has been associated with parenteral ketorolac tromethamine, but the risk that is associated with this therapy has not been quantified. OBJECTIVE To compare the risk for acute renal failure associated with ketorolac with that associated with opioids. DESIGN Retrospective cohort study. SETTING 35 hospitals in or near(More)
OBJECTIVE To evaluate the risk of gastrointestinal and operative site bleeding associated with the use of parenteral ketorolac tromethamine. DESIGN Postmarketing surveillance inception cohort study. SETTING A total of 35 hospitals throughout the Philadelphia, Pa, region, 1991 to 1993. PATIENTS Patients administered 10,272 courses of parenteral(More)
BACKGROUND Recent studies suggest that proton-pump inhibitors (PPIs) may increase the risk for community-acquired pneumonia (CAP). OBJECTIVE To examine the association between PPI use and CAP in adults followed in general practices in the United Kingdom. DESIGN Nested case-control study. SETTING The General Practice Research Database (1987 to 2002) in(More)
Statistical power in matched case-control studies depends on both the correlation coefficient between cases and their matched controls (phi) and the prevalence of exposure among controls (P0). To examine the hypothesis that the value of increasing the control-to-case ratio beyond 5 varies with both phi and P0, the authors estimated statistical power for a(More)