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Fragile X syndrome, the most common inherited form of human mental retardation, is caused by mutations of the Fmr1 gene that encodes the fragile X mental retardation protein (FMRP). Biochemical evidence indicates that FMRP binds a subset of mRNAs and acts as a regulator of translation. However, the consequences of FMRP loss on neuronal function in mammals(More)
Activation of group 1 metabotropic glutamate receptors (mGluRs) induces long-term depression (LTD) of synaptic transmission that relies on dendritic protein synthesis. We investigated the signal transduction pathways required for mGluR-LTD to identify candidate mechanisms for mGluR regulation of synaptic protein synthesis. Our results demonstrate a role for(More)
OBJECTIVES This study investigated the impact of procedural success on mortality following chronic total occlusion (CTO) percutaneous coronary intervention (PCI) in a large cohort of patients in the drug-eluting stent era. BACKGROUND Despite advances in expertise and technologies, many patients with CTO are not offered PCI. METHODS A total of 6,996(More)
STUDY DESIGN Spine loads associated with lifting a 9-kg weight were estimated at three torso flexion angles (0 degrees, 22.5 degrees, and 45 degrees), and lumbosacral motion segments were cyclically loaded using these loads until failure or to a maximum of 10,020 cycles. OBJECTIVES To simulate the postures and loads experienced by the lumbar spine during(More)
BACKGROUND Brain abnormalities of subcortical and limbic nuclei are common in patients with schizophrenia, and variation in these structures is considered a putative endophenotype for the disorder. Multiplex-multigenerational families with schizophrenia provide an opportunity to investigate the impact of shared genetic ancestry, but these families have not(More)
Patients with acute cardiac symptoms, elevated cardiac troponin and culprit-free angiograms comprise a significant proportion of patients admitted with presumed acute coronary syndromes (ACS). International guidelines recommend that these patients receive lifelong secondary prevention under the presumption that angiographically undetectable coronary artery(More)
Researchers at the National Institute for Occupational Safety and Health (NIOSH) are investigating different lighting technologies with the objective of improving mine safety. This paper presents the results from an ongoing study that compares discomfort glare for different light-emitting diode (LED) cap lamps using the de Boer glare rating scale. The cap(More)
8262 Background: PALO is the only 5-HT3 receptor antagonist (RA) approved by the FDA for prevention of acute & delayed CINV after moderately emetogenic CT. Aprepitant is a NK1 RA approved for prevention of acute & delayed CINV after highly emetogenic CT when used with a 5-HT3 RA & DEX. We now report the first study combining these novel antiemetics in(More)
AIM Primary percutaneous coronary intervention (PPCI) produces more effective coronary reperfusion and allows immediate risk stratification compared with fibrinolysis. We investigated the safety and feasibility of very early discharge at 2 days following PPCI in selected low-risk cases. METHODS This was a prospective observational cohort study of 2779(More)