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HIF-1a is overexpressed in many human cancers compared to normal tissues due to the interaction of a multiplicity of factors and pathways that reflect specific genetic alterations and extracellular stimuli. We developed two HIF-1a chimeric reporter systems, HIF-1a/FLuc and HIF-1a(DODDD)/FLuc, to investigate the tightly controlled level of HIF-1a protein in(More)
  • Sean Carlin, Nahida Khan, Thomas Ku, Valerie A. Longo, Steve M. Larson, Peter M. Smith-Jones
  • 2010
BACKGROUND Carbonic anhydrase IX (CAIX) is a membrane spanning protein involved in the enzymatic regulation of tumor acid-base balance. CAIX has been shown to be elevated in a number of hypoxic tumor types. The purpose of this study was to determine the efficiency of intact and IgG fragments of cG250 to target CAIX in vivo in a hypoxic tumor model. (More)
INTRODUCTION Oncolytic viruses show promise for treating cancer. However, to assess therapy and potential toxicity, a noninvasive imaging modality is needed. This study aims to determine the in vivo biodistribution, and imaging and timing characteristics of a vaccinia virus, GLV-1h153, encoding the human sodium iodide symporter (hNIS. METHODS GLV-1h153(More)
UNLABELLED The sodium/iodide symporter (NIS) has been identified as an attractive target for cancer therapy. The efficacy of (131)I-iodide for NIS-expressing tumor therapy may be limited by a combination of poor cellular retention and unfavorable physical characteristics (long physical half-life and low linear-energy-transfer [LET] radiative emissions). On(More)
  • Jeffrey M Glas, Jason Reifler, Ryan Committee, Sean Carlin, Richey
  • 2015
Do the physical settings in which a voter casts their ballot affect their vote choices? Every state uses a variety of polling locations for the administration of election: churches, schools, libraries, fire stations, and etcetera. The literature on priming effects and voting is massive, but very little research examines the impact of the venue in which a(More)
Accurate visualization and quantification of β-cell mass is critical for the improved understanding, diagnosis, and treatment of both type 1 diabetes (T1D) and insulinoma. Here, we describe the synthesis of a bimodal imaging probe (PET/fluorescence) for imaging GLP-1R expression in the pancreas and in pancreatic islet cell tumors. The conjugation of a(More)
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