Sean C Halligan

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An enormous number of studies in the last two decades have been devoted to investigating the role of the endothelium in cardiovascular diseases. Nonetheless, the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, molecular genetic tests and invasive and non-invasive tools(More)
BACKGROUND The natural history of atrial flutter is not well defined. OBJECTIVE To report the risk for stroke, conversion to atrial fibrillation, and anticoagulation for lone atrial flutter. DESIGN Retrospective cohort analysis. SETTING A clinically based longitudinal study of inpatients and outpatients with atrial flutter. PATIENTS The authors(More)
OBJECTIVES To determine the difference in endothelial function between premenopausal and postmenopausal women and to determine whether hormone replacement therapy (HRT) is associated with an improvement in coronary endothelial function. PATIENTS AND METHODS Women undergoing coronary physiology studies for chest pain at the Mayo Clinic In Rochester, Minn,(More)
We investigated whether the observed protective effect of hyperlipidemia is stronger in patients who take statins and, if so, whether that effect is likely due to patient characteristics associated with statin use. In-hospital complications and long-term outcomes of patients with hyperlipidemia (cholesterol level > or = 240 mg/dl) undergoing percutaneous(More)
Patients with chest pain and nonobstructive coronary artery disease (NOCAD) utilize a significant part of our health care resources. Their diagnosis and treatment can often be difficult and time consuming. A simple classification system and stepwise diagnostic approach may help to reduce unnecessary testing. Also, utilization of a chest pain clinic may be(More)
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