Sean A Gilman

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Lung cancer is the leading cause of death from cancer in the US and the world. The high mortality rate (80-85% within 5 years) results, in part, from a lack of effective tools to diagnose the disease at an early stage. Given that cigarette smoke creates a field of injury throughout the airway, we sought to determine if gene expression in histologically(More)
The North American Multiple System Atrophy Study Group involves investigators in 12 US medical centers funded by a grant from the National Institutes of Health. The objectives are to examine the environmental and genetic risk factors for MSA; elucidate pathogenic mechanisms underlying the disorder; and refine evaluations used for assessment. During its(More)
This review by a 10-member panel of experts in surgical prehabilitation addresses processes that may improve oncologic care. Surgical prehabilitation is the process on the continuum of care that occurs between the time of cancer diagnosis and the beginning of surgical treatment. The panel focused on the current state-of-the-science and recommended future(More)
RATIONALE Opioids are commonly used to relieve dyspnea, but clinical data are mixed and practice varies widely. OBJECTIVES Evaluate the effect of morphine on dyspnea and ventilatory drive under well-controlled laboratory conditions. METHODS Six healthy volunteers received morphine (0.07 mg/kg) and placebo intravenously on separate days (randomized,(More)
Although the current guidelines for the clinical diagnosis of multiple system atrophy (MSA) do not require structural or functional brain imaging, investigations utilizing positron emission tomography (PET) have been helpful diagnostically in differentiating between MSA and primary autonomic failure; idiopathic Parkinson’s disease; and sporadic(More)
Vol. 36, No. 3 (2004) BioTechniques 485 Swabs and scrapings from the buccal mucosa in the mouth have been used to obtain DNA from epithelial cells for genetic studies (1,2). RNA has been obtained from resected tissues and from biopsy samples of mouth epithelium in various disease states to measure gene expression (3,4). However, RNA has not been extracted(More)
Erectile dysfunction (ED) is a well-known entity with determined risk factors, which generally has a negative impact on quality of life. Obstructive sleep-disordered breathing (SDB), often referred to as obstructive sleep apnea, stands among the possible risk factors for ED. Literature review suggests that SDB induces a spectrum of abnormalities in neural,(More)
PURPOSE OF REVIEW To discuss the pathophysiology of dyspnea as it relates to patients suffering with chronic respiratory illness or end-stage disease. RECENT FINDINGS There are several publications highlighting important new concepts in this field including a new multidimensional model of dyspnea, similar to that developed for pain, that sheds new insight(More)
In freely moving rats, averaged evoked potentials (AAER) to paired click stimuli delivered at varying interstimulus intervals were recorded with semi-microelectrodes simultaneously in globus pallidus (GP), caudate nucleus (CN), and substantia nigra (SN). The effects of intrapentoneal injection of reserpine and L-Dopa on the neuronal recovery cycles were(More)