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Clustering nodes in a graph is a useful general technique in data mining of large network data sets. In this context, Newman and Girvan [9] recently proposed an objective function for graph clustering called the Q function which allows automatic selection of the number of clusters. Empirically, higher values of the Q function have been shown to correlate(More)
Brain morphometric studies often incorporate comparative hemispheric asymmetry analyses of segmented brain structures. In this work, we present evidence that common user guided structural segmentation techniques exhibit strong left-right asymmetric biases and thus fundamentally influence any left-right asymmetry analyses. In this study, MRI scans from ten(More)
OBJECTIVE To evaluate the effectiveness of using subchondral bone texture observed on a radiograph taken at baseline to predict progression of knee osteoarthritis (OA) over a 3-year period. METHODS A total of 138 participants in the Prediction of Osteoarthritis Progression study were evaluated at baseline and after 3 years. Fractal signature analysis(More)
OBJECTIVE To evaluate subchondral bone trabecular integrity (BTI) on radiographs as a predictor of knee osteoarthritis (OA) progression. METHODS Longitudinal (baseline, 12-month, and 24-month) knee radiographs were available for 60 female subjects with knee OA. OA progression was defined by 12- and 24-month changes in radiographic medial compartment(More)
AIM To evaluate potential drug interactions with antiretroviral therapies or supportive therapies for use in conjunction with the once daily, next generation non-nucleoside reverse transcriptase inhibitor GSK2248761 in patients with HIV-1 infection. METHODS A series of phase I drug interaction studies was conducted. RESULTS GSK2248761 was shown to be a(More)
— An out-of-order, three-way superscalar x86 microprocessor with a 15-stage pipeline, organized to allow 600-MHz operation, can fetch, decode, and retire up to three x86 instructions per cycle to independent integer and floating-point schedulers. The schedulers can simultaneously dispatch up to nine operations to seven integer and three floating-point(More)