Scott T. Brittain

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Microcontact printing (µCP) and wet chemical etching generated two-dimensional (2D) patterns in thin silver films. Electroplating silver onto these patterns increased the structural integrity of the metal layer. Separating the metal film from the substrate resulted in free-standing, 2D structures. Folding of these structures along predesigned " hinges "(More)
quenching to room temperature. As a result, the polarization bandwidth was found to increase by a factor of 2.4 over what was expected of a constant-pitch film. The increased bandwidth was attributed to a pitch gradient resulting from photoinduced racemization of the chiral dopant at the irradiated surface with simultaneous diffusion through the film. This(More)
This paper describes the fabrication and operating principles of a reconfigurable diffraction grating based on a microfluidic device. Ž. The device consists of an array of microscopic channels 50 mm wide and 20 mm deep defined by the conformal contact between a transparent elastomeric material that has an embossed surface relief and a flat glass substrate.(More)
This paper describes a practical method for the fabrication of photomasks, masters, and stamps/molds used in soft lithography that minimizes the need for specialized equipment. In this method, CAD files are first printed onto paper using an office printer with resolution of 600 dots/ in. Photographic reduction of these printed patterns transfers the images(More)
Ž This paper describes fabrication techniques for the fabrication of glassy carbon microstructures. Molding of a resin of poly furfuryl. alcohol using elastomeric molds yields polymeric microstructures, which are converted to free-standing glassy carbon microstructures by Ž. Ž 2. heating T ; 500–11008C under argon. This approach allows the preparation of(More)
Soft lithography offers a convenient set of methods for the transfer of patterns to planar and nonplanar substrates. Microelectrodeposition can transform thin metal patterns into self-supporting microstructures, weld components together, and strengthen microstructures after deformations. Together, soft lithography and electrochemistry provide synergistic(More)
This paper describes the fabrication of free-standing high-carbon microstructures by soft-lithographic techniques; these structures ranged in complexity from simple beams to complex, suspended deflectors. Microstructures of polymeric precursors (copolymers of furfuryl alcohol-phenol) to high-carbon solids were fabricated using poly(dimethylsiloxane) (PDMS)(More)
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent covalent MAGL inhibitor, SAR127303. The compound behaves as a selective and competitive inhibitor of mouse and human MAGL, which potently elevates hippocampal levels of 2-AG in mice. In vivo,(More)
In this article the fabrication and characterization of two thermally actuated optical devices for the measurement of temperature and power are described. A transparent polymer having a high coefficient of thermal expansion—poly͑dimethylsiloxane͒ ͑PDMS͒—was used as the temperature-sensitive medium. Changes in the dimensions of the polymer on heating caused(More)
Enediynes were first shown by Bergman to undergo thermal intramolecular cyclization to reactive aryl 1,4-diradical intermediates. 1 A variety of enediyne-containing compounds have since been pursued for their potential biological activity as antitumor drugs. 2 More recently, the Bergman cyclization was used to prepare linear polyarylenes by chemical vapor(More)