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The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses.
OBJECTIVE The genes encoding the gamma-aminobutyric acid(A) (GABA(A)) receptor have been the focus of several recent studies investigating the genetic etiology of alcohol dependence. Analyses ofExpand
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Amygdala Volume in Offspring from Multiplex for Alcohol Dependence Families: The Moderating Influence of Childhood Environment and 5-HTTLPR Variation.
BACKGROUND The increased susceptibility for developing alcohol dependence seen in offspring from families with alcohol dependence may be related to structural and functional differences in brainExpand
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  • Open Access
Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes.
AIM Familial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study. MATERIALS & METHODS Growth curve analyses ofExpand
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ACN9 and alcohol dependence: Family‐based association analysis in multiplex alcohol dependence families
A previous genome‐wide linkage study of alcohol dependence (AD) in the Pittsburgh‐based multiplex family study found suggestive evidence for linkage on Chromosome 7q, a region in which the ACN9 geneExpand
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Cholinergic receptor gene (CHRM2) variation and familial loading for alcohol dependence predict childhood developmental trajectories of P300
P300 amplitude in childhood predicts substance use disorders by young adulthood. Trajectories of visual P300 amplitude show an association between low amplitude P300 and familial risk for alcoholExpand
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ASTN1 and alcohol dependence: Family‐based association analysis in multiplex alcohol dependence families
A previous genome‐wide linkage study of alcohol dependence (AD) in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 and D1S2878.Expand
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Longitudinal predictors of cannabis use and dependence in offspring from families at ultra high risk for alcohol dependence and in control families
Cannabis use is common among adolescents. Identification of the factors associated with continued heavy use into young adulthood and development of cannabis abuse and dependence is of considerableExpand
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Improving the power-performance of multicore processors through optimization of lithography and thermal processing
It is generally assumed that achieving a narrow distribution of physical gate length (Lpoly) for the poly conductor layer helps improve power performance metrics of modern integrated circuits.Expand
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Family-based association analysis of alcohol dependence implicates KIAA0040 on Chromosome 1q in multiplex alcohol dependence families
Background A previous genome-wide linkage study of alcohol dependence in multiplex families found a suggestive linkage result for a region on Chromosome 1 near microsatellite markers D1S196 andExpand
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  • Open Access
Model-based correction for local stress-induced overlay errors
Manufacturing embedded DRAM deep trench capacitors can involve etching very deep holes into silicon wafers1. Due to various design constraints, these holes may not be uniformly distributed across theExpand
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