Scott Sommers

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The specific biochemical steps required for glucose-regulated insulin exocytosis from beta-cells are not well defined. Elevation of glucose leads to increases in cytosolic [Ca2+]i and biphasic release of insulin from both a readily releasable and a storage pool of beta-granules. The effect of elevated [Ca2+]i on phosphorylation of isolated beta-granule(More)
Insulin secretory dysfunction of the pancreatic beta-cell in type-2 diabetes is thought to be due to defective nutrient sensing and/or deficiencies in the mechanism of insulin exocytosis. Previous studies have indicated that the GTP-binding protein, Rab3A, plays a mechanistic role in insulin exocytosis. Here, we report that Rab3A(-/-) mice develop fasting(More)
This study focused on emotional range--a personality variable introduced to the study of emotion. It is argued that individual differences in emotional responsiveness need to be described and analyzed not only in terms of emotional intensity but also in terms of emotional range. What are some of the factors that influence an individual's range of emotional(More)
Previous studies have demonstrated that arguments incompatible with prior beliefs are subjected to more extensive refutational processing, scrutinized longer, and judged to be weaker than arguments compatible with prior beliefs. However, this study suggests whether extensive processing is implemented when evaluating arguments is not decided by argument(More)
Continuous elevation of intracellular cyclic AMP (cAMP) by culturing neuroblastoma x glioma NG108-15 hybrid cells in the presence of forskolin and isobutylmethylxanthine (IBMX) in a chemically defined medium resulted in differentiation of the hybrid cells, as indicated by extension of neurite-like structures and induction of a subclass of G-protein, Go, as(More)
A growing trend throughout the United States is an increasing willingness of cities to publicly finance professional sports stadiums. The stadiums are justified by tangible economic benefits, either citywide or specific to a targeted region through a revitalization plan. The citywide economic impact arising from a new professional sports stadium, when(More)
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