Scott Solomon

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Estimation of the regional mechanical properties of the cardiac muscle has been shown to play a crucial role in the detection of cardiovascular disease. Current echocardiography-based cardiac motion estimation techniques, such as Doppler Myocardial Imaging (DMI), are limited due to angle dependence. By contrast, elastography, a method designed and used for(More)
AIMS Although active-controlled trials with renin–angiotensin inhibitors are ethically mandated in heart failure with reduced ejection fraction, clinicians and regulators often want to know how the experimental therapy would perform compared with placebo. The angiotensin receptor-neprilysin inhibitor LCZ696 was compared with enalapril in PARADIGM-HF. We(More)
AIMS Increased sympathetic activation and reduced parasympathetic tone are important pathophysiological contributors to the progression of heart failure, and are associated with poor outcome in patients. The aim of this study is to determine if vagal nerve stimulation (VNS) is a promising approach to modulate autonomic function and slow cardiac remodelling(More)
Excessive avoidance and diminished approach behavior are both prominent features of anxiety, trauma and stress related disorders. Despite this, little is known about the neuronal mechanisms supporting gating of human approach-avoidance behavior. Here, we used functional magnetic resonance imaging (fMRI) to track dorsal anterior cingulate and medial(More)
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