Scott M. Warden

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The AMP-activated protein kinase (AMPK) is a ubiquitous mammalian protein kinase important in the adaptation of cells to metabolic stress. The enzyme is a heterotrimer, consisting of a catalytic alpha subunit and regulatory beta and gamma subunits, each of which is a member of a larger isoform family. The enzyme is allosterically regulated by AMP and by(More)
The Wnt signaling pathway is highly conserved among species and has an important role in many cell biological processes throughout the body. This signaling cascade is involved in regulating ocular growth and development, and recent findings indicate that this is particularly true in the retina. Mutations involving different aspects of the Wnt signaling(More)
Microvascular manipulation is one application in the emerging field of retinal vascular surgery that could lead to new therapeutic approaches for retinal disease. Research in this field has largely focused on vessel cannulation and injection of vasoactive substances. This study expands on applications for retinal vessel manipulation by demonstrating that(More)
This study examines the use of a devitalized biological knee as a scaffold for repopulation with chondrocytes and tests the hypothesis that the devitalized scaffold would become repopulated with the foreign chondrocytes when placed in a suitable environment. Chimeric knee constructs were engineered in vitro and their ectopic in vivo fate was examined in(More)
PURPOSE To describe a case of hemorrhagic retinopathy secondary to aplastic anemia caused by 6-mercaptopurine. METHODS A case report of a patient who presented as an outpatient to the Ophthalmology service of the New York Presbyterian Hospital. CONCLUSION To the authors' knowledge, this is the first reported case of hemorrhagic retinopathy secondary to(More)
PURPOSE To evaluate the state of the retina overlying a subretinal abscess and its contents by histopathologic analysis and electron microscopy (EM) and to determine implications for treatment. METHODS Case report of a patient with a subretinal abscess secondary to Klebsiella pneumoniae infection who underwent pars plana vitrectomy, PPL, endolaser,(More)
PURPOSE To describe an intraocular contact lens presenting as a foreign body 1 year after repair of a traumatic open globe. METHOD A case report. RESULTS The patient underwent open globe repair for a scleral laceration. The patient's vision returned to 20/20 and had no ocular complaints until 1 year later when he had a large floater. Examination(More)
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