Scott L Fahrner

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Previous studies on cycling cadence have focused on the economy of the cadence, in search of the optimal pedal cadence. The purpose of this study was to determine the hemodynamic changes associated with varying pedal cadence at a constant workload. It was hypothesized that increased pedal cadence would enhance the skeletal muscle pump, resulting in(More)
OBJECTIVE To test the effect in normal human volunteers of transient systemic inflammation on the variability in time-series behaviors of widely divergent physiologic measures of the human inflammatory response. DESIGN Prospective study of human volunteers who were tested on 2 consecutive days, a control day and a treatment day. Each participant served as(More)
Although haptoglobin polymorphism has been shown to be a genetic risk factor in coronary artery disease, its mechanisms of action are incompletely defined. Recently, a macrophage scavenger receptor for the uptake of haptoglobin-hemoglobin (Hp-Hb) complexes was cloned and designated CD163. Macrophage expression of CD163 is increased by glucocorticoids, IL-10(More)
BACKGROUND Multiple investigations have demonstrated that hypertonic saline (HS) diminishes the response of polymorphonuclear leukocytes (PMNs) to stimulation. Recent meta-analysis suggests that hypertonic saline in dextran (HSD) is clinically superior to HS. No work to date has examined the effect of added dextran on this immunomodulatory property. (More)
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